Also Known as RoAccutane
Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Accutane is the brand name for Isotretinoin and is a potent medication that dermatologists prescribe for severe acne cases that haven't improved with other treatments. It belongs to a class of drugs known as retinoids, which are closely related to vitamin A. This medication operates by significantly reducing the size and output of the skin's oil glands, which helps to reduce acne by making the environment less conducive to the growth of bacteria. Additionally, isotretinoin supports quick skin cell renewal, assisting in the clearance of acne and, in many cases, preventing new pimples from forming.
| Fact Table | |
| Formula | C20H28O2 |
| License | US FDA |
| Bioavailability | Highly variable (25-60%) |
| Legal status | Prescription only (Rx) |
| Chemical Name | 13-cis-Retinoic Acid |
| Elimination half-life | 10-20 hours |
| Dosage (Strength) | 10 mg, 20 mg, 40 mg capsules |
| Pregnancy | Not for use in pregnancy (Category X) |
| Brands | Accutane, Claravis, Amnesteem, Absorica |
| Protein binding | 99.9% |
| PubChem CID | 5282379 |
| MedlinePlus | a681043 |
| ChEBI | CHEBI:6067 |
| ATC code | D10BA01 |
| DrugBank | DB00982 |
| KEGG | D00348 |
| Routes of administration | Oral |
Patients typically take Accutane pills once or twice daily, following the instructions of their healthcare provider. The standard dosage may vary, but it's crucial to take Isotretinoin with food to enhance absorption. Since the drug is available in capsule form, it’s important to swallow it whole to ensure the correct dosage. It's important to adhere strictly to the prescribed regimen and not to take more or less than directed, as changes can greatly affect efficacy and safety.
The active ingredient in Accutane is Isotretinoin.
Avoid taking or using this medication if any of the following apply:
Accutane commonly leads to skin and lip dryness, mirroring the effects of high doses of vitamin A. Users often report symptoms such as dry lips, dry nasal passages causing nosebleeds, and dry eyes. Other frequent side effects include nausea, headache, fatigue, skin rash, and joint pain. The medication is also known to cause increased blood triglyceride levels and cheilitis (cracked lips), which are generally dose-dependent.
More severe health issues associated with Accutane include liver problems, an increased likelihood of tendon damage, and changes in blood sugar levels, which could prompt diabetic symptoms. Significant psychiatric effects, such as depression and suicidal thoughts, have been reported. Vision-related side effects, like decreased night vision, hearing impairment, and severe allergic reactions, are serious concerns. Accutane can also affect bone health, lead to severe skin reactions, and cause muscle pain. Due to these potential risks, it's important to stay in close contact with your healthcare provider and report any serious or persistent side effects right away.
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