Afinitor Disperz (Everolimus)

Description

Afinitor Disperz, also known by its generic name Everolimus, is a medication that acts as an mTOR (mammalian target of rapamycin) inhibitor, a type of drug that may help regulate cell growth, proliferation, and survival of cancer. It's typically used to treat a variety of conditions, including certain types of tumors and seizures associated with tuberous sclerosis complex (TSC) in both adults and children aged 2 years and above. By blocking mTOR, Afinitor Disperz can slow down the growth of cancer cells and reduce the frequency of seizures for those with TSC.

Directions

Patients should take Afinitor Disperz exactly as prescribed by a healthcare professional. The standard Afinitor Disperz dosage typically involves dispersing the tablet to form a suspension, which is then taken orally. Afinitor Disperz should not be chewed or crushed. The dosage will depend on the condition being treated, but the drug is usually taken once daily. The suspension should be administered within 60 minutes of preparation.

Ingredients

The active ingredient in Afinitor Disperz is Everolimus. The medication may also contain inactive ingredients to support the stability and absorption of the active ingredient.

Contraindications

Avoid taking this medication if you have a known or suspected hypersensitivity to Everolimus, rapamycin derivatives, or any ingredients in the drug.

Cautions

• Before taking Afinitor Disperz, be sure to consult a healthcare provider about the following:
• Whether you have any allergies
• If you have other medical conditions
• If you take other medications
• Whether you’re pregnant or breastfeeding
• Afinitor Disperz can cause lung problems (pneumonitis). Be alert for symptoms like coughing and difficulty breathing. Depending on the severity, Afinitor Disperz may need to be withheld or discontinued.
• This medication can increase your risk of infections. Watch for signs of infection and inform your healthcare provider if any occur. Treatment may need to be adjusted based on the severity of the infection.
• If you experience significant allergic reactions to Afinitor Disperz, it should be permanently discontinued.
• If you're taking ACE inhibitors, you may be at an increased risk of angioedema (swelling under the skin). Afinitor Disperz should be stopped permanently if angioedema occurs.
• To help prevent mouth sores (stomatitis), consider using a dexamethasone alcohol-free mouthwash when starting treatment.
• Before and during treatment with Afinitor Disperz, your kidney function should be monitored.
• If you're planning to undergo surgery, it's recommended to withhold Afinitor Disperz for at least one week prior to elective surgery and not administer it for at least two weeks after major surgery until adequate wound healing is observed.
• Elderly patients may require dose adjustments due to adverse reactions.
• Monitor your serum glucose and lipid levels before starting treatment and periodically thereafter. Treatment adjustments may be necessary depending on the severity of metabolic disturbances.
• Afinitor Disperz can affect blood cell counts. Regular monitoring of blood parameters is advised, and adjustments to treatment may be needed based on the results.
• Avoid live vaccines and close contact with anyone who has recently received a live vaccine. Ensure all recommended vaccinations are completed before starting treatment.
• Afinitor Disperz can intensify radiation therapy reactions. Inform your doctor if you are undergoing radiation therapy.
• Afinitor Disperz can harm an unborn baby. Patients of reproductive potential should be advised about this risk and use effective contraception.

Side Effects

Afinitor Disperz is associated with infections, rash, fatigue, diarrhea, swelling in various body parts, abdominal pain, nausea, fever, cough, headache, and decreased appetite. Serious side effects may include impaired wound healing and increased blood sugar and fat levels, necessitating careful monitoring. Decreased blood cell counts and worsened radiation therapy side effects are also risks. Patients should discuss any surgery plans with their healthcare provider, as well as any concerns about fertility or menstrual changes. Regular blood tests are advised, and immediate medical attention is recommended for severe symptoms.

References:

1. Afinitor Disperz (Everolimus) Product Monograph. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2022.
2. Afinitor Disperz (Everolimus) Drug Label Information. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2023.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....