Alunbrig (Brigatinib)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
Starter Kit (90mg tab for 7 days & 180mg tab for 21 days)
Pack Size
Qty
Strength
180mg
Pack Size
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Alunbrig (Brigatinib) is a medication used to treat adults with a type of lung cancer called metastatic non-small cell lung cancer (NSCLC). This cancer has a specific change in a gene called anaplastic lymphoma kinase (ALK). Brigatinib works by blocking certain proteins that help cancer cells grow and spread. It is especially useful for patients whose cancer keeps getting worse after they have been treated with another medication called Crizotinib.

Directions

Alunbrig is an oral medication taken once daily, starting with a 90 mg dose for the first seven days, after which it may be increased to 180 mg based on tolerance and medical advice. Treatment should continue until disease progression or unacceptable toxicity occurs. If the medication is interrupted for 14 days or longer for reasons other than adverse reactions, resume at 90 mg daily for seven days before returning to the previously tolerated dose. Alunbrig can be taken with or without food, and patients should swallow the tablets whole without crushing or chewing them. If a dose is missed or vomiting occurs after taking a dose, do not take an additional dose; instead, continue with the next scheduled dose.

Ingredients

The active ingredient in Alunbrig is Brigatinib.

Contraindications

There are no contraindications mentioned on the drug label. However, you should not take this medication if you are allergic to Brigatinib or any of its ingredients.

Cautions

  • Before initiating treatment with Alunbrig, provide your healthcare provider with the following information:
    • Existing health conditions
    • Known allergies
    • A list of all the medications you are currently taking
    • Your pregnancy or breastfeeding status
  • Severe lung issues, including ILD or pneumonitis, can occur, often within the first few weeks. If new or worsening respiratory symptoms appear, stop treatment and evaluate immediately.
  • High blood pressure is common. Regular monitoring is essential, and if severe hypertension develops, treatment may need to be paused or the dose reduced.
  • Alunbrig can cause slow heart rate (bradycardia). Monitor heart rate and watch for symptoms like dizziness or chest discomfort. Adjust treatment if necessary.
  • Vision changes, including blurred vision and light sensitivity, can occur. Patients should report any new symptoms, and treatment may need to be adjusted based on severity.
  • Muscle pain and elevated CPK levels are common. Regular CPK monitoring is advised, and adjustments may be required if levels are too high.
  • Elevated pancreatic enzymes may occur, requiring dose reduction or temporary treatment interruption if severe.
  • Liver damage is a potential risk. Regular liver function tests are recommended, and treatment should be stopped if serious liver issues develop.
  • Blood sugar levels can rise, so regular monitoring is necessary, and adjustments to diabetes management may be needed.
  • Sun sensitivity can increase. Use sunscreen and protective clothing to minimize exposure.
  • Alunbrig can harm a developing fetus. Women should use contraception during treatment and for 4 months afterward, and men should use contraception for 3 months after the last dose.

Side Effects

The most common side effects of Alunbrig include diarrhea, fatigue, nausea, vomiting, and muscle pain. You may also experience a cough, high blood pressure, headaches, or difficulty breathing. Some patients report changes in vision, such as blurriness or double vision, but these symptoms tend to be manageable. Make sure to talk to your doctor if any of these side effects become bothersome.

Alunbrig can cause more serious side effects, such as lung problems, including inflammation, which may lead to difficulty breathing, chest pain, or a persistent cough. It may also cause high blood pressure and slow heart rate, which can lead to dizziness or fainting. If you experience these symptoms or notice signs of liver issues like yellowing of the skin, dark urine, or severe stomach pain, seek medical attention immediately. Regular check-ups and blood tests will help monitor for any serious reactions during treatment.

References

  1. Alunbrig (Brigatinib) Product Monograph. Lexington, MA: Takeda Pharmaceuticals America, Inc.; 2022.
  2. Alunbrig (Brigatinib) Drug Label Information. Lexington, MA: Takeda Pharmaceuticals America, Inc.; 2023.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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