Amjevita (Adalimumab)

Description

Amjevita (adalimumab-atto) is a prescription medication that is injected underneath the skin to treat the following: rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis.

Amjevita comes in single-dose prefilled syringes and autoinjectors that contain the following concentrations of the medication:

• Single-dose prefilled syringes:
• 10 mg/0.2 mL
• 20 mg/0.2 mL
• 20 mg/0.4 mL
• 40 mg/0.4 mL
• 40 mg/0.8 mL
• 80 mg/0.8 mL
• Single-dose prefilled SureClick^® autoinjectors:
• 40 mg/0.4 mL
• 40 mg/0.8 mL
• 80 mg/0.8 mL

Directions

Your doctor will decide on an appropriate treatment regimen for you, including an Amjevita dosage, depending on if you are an adult or a pediatric patient, how much you weigh, and the condition you have that needs treatment. You or your caregiver will be provided instructions on how to properly prepare, administer, and discard Amjevita. The medication guide that comes with your prescription contains more detailed information regarding its use.

Inject Amjevita underneath the skin of the thigh or abdomen. Rotate injection sites with each administration. Needles or syringes should not be shared with others.

Speak to your doctor or pharmacist if you have any questions or concerns.

Storage:

Store Amjevita in its original container; refrigerate Amjevita between 36°F and 46°F (2°C to 8°C). Do not freeze the medication, and do not use it even if it has been thawed.

Amjevita may be stored at room temperature (do not exceed 77°F, or 25°C) and away from exposure to light for up to 14 days if needed.

Ingredients

Adalimumab-atto is the active ingredient contained in Amjevita. Glacial acetic acid, polysorbate 80, sucrose, and Water for Injection are the inactive ingredients contained in Amjevita. To adjust pH, sodium hydroxide may be added.

Contraindications

There are no contraindications for Amjevita per the most recent Prescribing Information. Treatment options should be discussed between patients and doctors.

Cautions

• Amjevita is associated with the following FDA Boxed Warnings:

• The risk of serious infections, including tuberculosis (TB), bacterial sepsis, invasive fungal infections, and other opportunistic infections, that can lead to hospitalization or cause death is increased.
• If a patient develops an infection or sepsis, Amjevita should be discontinued.
• Evaluation for latent TB should occur, and treatment should be started in the case of a positive test.
• Patients should receive TB monitoring during Amjevita treatment.
• Lymphoma and other cancers that can be fatal have developed in children and adolescents who were treated with TNF-blockers like adalimumab.
• Adolescents and young adults with inflammatory bowel disease who were treated with TNF-blockers like adalimumab have developed hepatosplenic T-cell lymphoma, a rare type of T-cell lymphoma.

• Before you start treatment with Amjevita, tell your doctor:
• About all prescription and nonprescription medications you take
• If you have any allergies
• About your medical history
• About your current health conditions
• If you are pregnant or breastfeeding
• The following may be caused by Amjevita:
• Amjevita has the potential to cause severe infections, including invasive fungal infections. Therefore, if you currently have an infection, it is not recommended to start treatment with Amjevita. In the event of developing an infection during Amjevita treatment, discontinuation may be necessary.
• An increased cancer risk
• Serious allergic reactions such as anaphylaxis
• Reactivation of hepatitis B. Individuals carrying the virus should undergo monitoring during and for several months following Amjevita therapy. If there is a reactivation of hepatitis B, Amjevita treatment should be stopped and hepatitis B treatment should be initiated.
• Demyelinating disease that develops or gets worse
• Decreased red blood cell, white blood cell, and platelet levels
• Heart failure that develops or gets worse
• Lupus-like syndrome

Side Effects

Some, but not all, side effects associated with Amjevita include infections, injection site reactions, headache, and rash. If you develop bothersome or persistent side effects, immediately notify your doctor.

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Reference

Amjevita. Thousand Oaks, CA: Amgen, Inc.; 2023.

About Dr. Savannah Muncy (Page Author)

Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....