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Lopidine Eye Drops (Apraclonidine)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
5mg
Pack Size
Qty
What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

IOPIDINE (apraclonidine) is a prescription eye medication that is used to treat open-angle glaucoma.

Open-angle glaucoma is a condition where fluid builds up in one or both eyes. The increased fluid causes pressure to the optic nerve that can lead to vision damage or blindness. 

IOPIDINE is an alpha-adrenergic agonist. It works by binding to alpha-receptors in the eye and reducing the formation of aqueous humor. The decreased production of fluid reduces intraocular pressure and protects the optic nerve.

Fact Table

Formula

C9H10Cl2N4

License

US FDA

Bioavailability

-

Legal status

Rx-Only

Chemical Name

Apraclonidine

Elimination half-life

8 hours

Dosage (Strength)

5mg

Pregnancy

Consult Doctor

Brands

Iopidine

Protein binding

98.7%

PubChem CID

2216

MedlinePlus

a608005

ChEBI

2788

ATC code

S01EA03

DrugBank

DB00964

KEGG

D07461

Routes of administration

Topical (ophthalmic solution)

Directions

Place one to two drops into the affected eye(s) three times daily as directed by the healthcare provider.

If you wear contact lenses, wait 15 minutes after the application of IOPIDINE to place them.

Avoid touching the tip of the eyedropper to the eye's surface because this can contaminate the medication and lead to eye infections.

Ingredients

Apraclonidine is the active ingredient in IOPIDINE.

Inactive ingredients include benzalkonium chloride, hydrochloric acid, purified water, sodium acetate, sodium chloride, and sodium hydroxide.

Interactions

Eye medications typically do not interact with other medications because they are not absorbed into the bloodstream. However, tell your healthcare provider if you are taking any of the following:

  • Alcohol
  • Anti-diabetic agents
  • Antihypertensives
  • Barbiturates
  • Beta-blockers
  • Digoxin
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Sedatives
  • Tricyclic antidepressants

Cautions

Use caution if you have a history of the following conditions: kidney impairment, liver impairment, cardiovascular disease, uncontrolled hypertension, recent heart attack, cerebrovascular disease, Raynaud's disease, or thromboangiitis obliterans.

Side Effects

Apraclonidine side effects may include:

  • Blanching
  • Blurred vision
  • Conjunctivitis
  • Discharge
  • Discomfort
  • Dry eye
  • Dry mouth
  • Eyelid edema
  • Foreign body sensation
  • Hyperemia
  • Pruritus
  • Tearing

References

Iopidine [package insert].Fort Worth, Texas: Alcon Laboratories; 2016.


IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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April 16, 2025 by Elizabeth A. (Washington, United States)
“Easy and streamlined way to order”
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April 16, 2025 by William C. (Connecticut, United States)
“Always happy with my service and products. Saves me a lot on my prescription.”
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April 16, 2025 by Cara C. (Texas, United States)
“Fast, well priced”
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April 16, 2025 by Nancy M. (Maine, United States)
“So easy!”
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April 16, 2025 by Sheila C. (Georgia, United States)
“Easy ordering, found medication I was searching for”
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April 16, 2025 by Marcia S. (PA, United States)
“Customer service was very responsive to my issue and followed up several times with updates concerning progress toward resolution. I am extremely pleased.”
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April 16, 2025 by Lauren C. (Alabama, United States)
“Great product/customer service.”
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April 15, 2025 by Geno (WA, United States)
“Great service from everyone working at Canada Drugs Direct!”
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April 15, 2025 by Kathleen H. (Colorado, United States)
“EASY TO ORDER ONLINE”
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April 15, 2025 by Gloria B. (South Carolina, United States)
“Easy to order. Thank you”