Beovu (Brolucizumab)

Prescription medicineOnly Available By Prescription

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Description

Beovu (Brolucizumab) is an eye injection used to treat neovascular (wet) age-related macular degeneration (AMD) and diabetic macular edema (DME). It works by inhibiting vascular endothelial growth factor (VEGF), a protein that promotes abnormal blood vessel formation in the eye. Beovu helps to manage the growth of these vessels, aiming to preserve vision in patients with AMD or DME. Beovu is administered as an injection into the eye by healthcare professionals.

Fact Table

Formula

C1428H2280N404O442S10

License

US FDA, EMA

Bioavailability

N/A (Intravitreal)

Legal status

Prescription only (Rx)

Chemical Name

Brolucizumab-dbll

Elimination half-life

~4.4 days (ocular)

Dosage (Strength)

6 mg/0.05 mL solution (Intravitreal injection)

Pregnancy

Consult a doctor (Category C)

Brands

Beovu

Protein binding

High (to VEGF-A)

PubChem CID

126313196

MedlinePlus

a620043

ChEBI

CHEBI:177749

ATC code

S01LA06

DrugBank

DB14761

KEGG

D11250

Routes of administration

Intravitreal injection

Directions

Beovu is injected directly into the eye by a healthcare professional trained in administering intravitreal injections. The typical starting dose is 6 mg (0.05 mL of a 120 mg/mL solution). Patients typically receive this dose once every month for the first three doses for AMD or once every six weeks for the first five doses for DME. Afterward, the dosing frequency may change to once every eight to twelve weeks as directed by a physician. It's important for patients to follow their doctor's specific instructions about follow-up appointments and treatment schedules.

Ingredients

Brolucizumab-dbll is the active ingredient in Beovu.

Contraindications

Avoid taking or using this medication if any of the following apply:

  • Previous Allergic Reactions: Patients with a known allergy to Brolucizumab or any of the components in Beovu
  • Active Infection: Presence of any infection in or around the eyes
  • Active Intraocular Inflammation: Signs of inflammation inside the eye, such as iritis or uveitis

Cautions

  • Talk to a healthcare provider about any of the following before starting treatment:
    • Any allergies
    • Other medications you’re taking
    • Other medical conditions you have
    • Whether you’re pregnant or breastfeeding
  • Intravitreal injections of Beovu carry a risk of serious eye conditions like endophthalmitis (a severe eye infection) and retinal detachment. You should be aware of symptoms such as eye pain, blurred vision, or seeing flashes of light and report them to your doctor immediately.
  • Following Beovu injections, there have been reports of retinal vasculitis and retinal vascular occlusion, which are conditions related to inflammation and blockage of blood vessels in the eye. It's important to monitor any vision changes and contact your eye specialist promptly if you notice any alterations.
  • After receiving a Beovu injection, the pressure inside your eye (intraocular pressure or IOP) can increase rapidly, sometimes within just 30 minutes. Regular eye pressure checks are important.
  • VEGF inhibitors like Beovu used in the eye have a potential risk associated with arterial thromboembolic events (such as heart attacks or strokes). Be aware of this risk, especially if you have pre-existing heart conditions.

Side Effects

In treating eye conditions, Beovu commonly causes blurred vision, cataracts (cloudy areas in the eye lens), eye bleeding, floaters (tiny spots in your vision), eye pain, increased eye pressure, and eye redness or irritation. Patients might also experience eye dryness, increased tearing, sensations of something in the eye, and vision changes.

More severe issues with Beovu include serious allergic reactions, infections inside the eye, retina detachment (the back layer of the eye pulling away), blood vessel blockages in the retina, and significantly increased eye pressure. Patients should promptly report any sudden vision changes, intense eye pain, or major discomfort to their healthcare provider. Regular eye check-ups are important for those on Beovu treatment.

References:

  1. Beovu (Brolucizumab) Product Monograph. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2023.
  2. Beovu (Brolucizumab) Drug Label Information. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2023.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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