Carafate (Sucralfate)

Description

Carafate, also known as Sucralfate, is a medication used mainly to treat active duodenal ulcers, which are sores in the first part of the small intestine. It works by creating a protective layer over the ulcer, helping to shield it from stomach acid and allowing it to heal. Sucralfate belongs to a group of medications called gastroprotective agents, which help protect the lining of the digestive system. While doctors usually prescribe this drug for duodenal ulcers, it may sometimes be used for other digestive problems that need a protective barrier.

Directions

Carafate should be taken orally, typically on an empty stomach. The standard dosage usually involves taking 1 gram, four times daily for a duration of 4 to 8 weeks. It's important not to eat at least 1 hour before and 2 hours after taking Carafate to maximize its effects. It's also important to avoid taking antacids within 30 minutes before or after Carafate, as they can interfere with the medication's action. Always consult a healthcare provider for the appropriate Carafate dosage and instructions.

Ingredients

The active ingredient in Carafate is Sucralfate.

Contraindications

Avoid taking or using this medication if you have an allergy to Sucralfate or any components of the Carafate formulation.

Cautions

• Before using Carafate, be sure to tell your healthcare provider if you have:
• Any current health conditions
• Any allergies
• A complete list of medications you are taking
• If you are pregnant or breastfeeding

• If you have diabetes, Carafate may cause episodes of high blood sugar. Regular blood sugar checks are recommended, and your doctor may need to adjust your diabetes medications.
• Carafate contains aluminum, which can build up in your body if your kidneys don’t work well. This can lead to serious complications like bone or brain disorders. If you have chronic kidney disease or are on dialysis, talk to your doctor about the risks and benefits of Carafate.
• Carafate can interfere with how your body absorbs certain medications, like antibiotics, heart medicines, and thyroid hormones. To avoid this, take other medications at least two hours before Carafate. Discuss all your medications with your doctor to ensure proper timing and effectiveness.
• Animal studies suggest that Carafate is unlikely to harm a developing baby, but there isn’t enough research in pregnant women. If you’re pregnant or breastfeeding, use Carafate only if absolutely necessary and under medical advice.
• Carafate hasn’t been proven safe or effective for children. For older adults, doctors usually start with a lower dose because kidney function often decreases with age. Monitoring kidney health is important during treatment.

Side Effects

The most commonly reported side effect of Carafate in clinical trials was constipation, affecting about 2% of patients. Other less common side effects, reported in fewer than 0.5% of cases, included nausea, vomiting, flatulence, diarrhea, and gastric discomfort. Some patients also experienced dizziness, headache, and rash, though these were rare and typically mild.

Post-marketing reports have included serious allergic reactions, including life-threatening ones like anaphylaxis, facial swelling, and skin rashes. There have also been issues with breathing, such as wheezing and swelling in the throat. In addition, some patients with certain health conditions, like slow stomach emptying or those receiving nutrition through feeding tubes, developed a blockage in their intestines known as a bezoar. If you notice any severe or unusual symptoms, it’s important to contact a healthcare provider right away.

References

1. Carafate (Sucralfate) Product Monograph. Bridgewater, NJ: Aptalis Pharma US, Inc.; 2013.
2. Carafate (Sucralfate) Drug Label Information. Irvine, CA: Allergan, Inc.; 2023.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....