Cardizem LA (Diltiazem Long Acting)

Description

Cardizem LA contains Diltiazem, a medication known as a calcium channel blocker. It is used to treat high blood pressure and chest pain, which is also known as angina. It works by relaxing the blood vessels, making it easier for blood to flow and reducing the pressure on the heart. Cardizem LA is available as extended-release tablets, meaning the medicine is released into the body slowly over time, providing longer-lasting effects compared to regular tablets.

Directions

Cardizem LA should be taken orally once per day, ideally at the same time every day to maintain consistent blood levels of the medication. The tablets should be swallowed whole and not crushed or chewed, as this helps the medicine work properly over time. When starting treatment for high blood pressure, the usual dosage is between 180 to 240 mg once daily, but healthcare providers may adjust the dosage based on how well the medication works for each person.

Ingredients

The active ingredient in Cardizem LA is Diltiazem.

Contraindications

Avoid taking or using this medication if any of the following apply:

• Known hypersensitivity to Diltiazem or any of the ingredients in the medication
• Sick sinus syndrome except in the presence of a functioning ventricular pacemaker
• Second- or third-degree AV block unless a functioning ventricular pacemaker is present
• Hypotension (systolic pressure less than 90 mm Hg or less than 30 mm Hg below baseline)
• Acute myocardial infarction and pulmonary congestion documented by x-ray on admission

Cautions

• Before taking Cardizem LA, you may need to consult a healthcare provider about the following:
• Any existing health conditions
• Any allergies
• A list of all medications you are currently taking
• Whether you are pregnant or breastfeeding

• Cardizem LA can slow down your heart rate, which may be a problem if you already have certain heart conditions like sick sinus syndrome or AV block. Taking Cardizem LA with beta-blockers or digitalis (another heart medication) can make this effect stronger. In rare cases, people have experienced brief pauses in heart activity (asystole).
• If you have heart failure or weakened heart function, Cardizem LA may make it worse. Be sure to tell your doctor if you’ve ever been diagnosed with heart failure. Using this medicine with beta-blockers in people with heart issues should be done carefully and under close medical supervision.
• Cardizem LA can sometimes affect your liver. In some people, liver enzymes may rise (which shows liver stress), and rarely, signs of acute liver injury have occurred. These effects tend to appear within the first 1 to 8 weeks of treatment and usually go away after stopping the medication. Mild changes in liver tests may not need treatment, but your doctor may monitor your liver function if needed.
• In very rare cases, Cardizem LA has been linked to severe skin reactions, including Stevens-Johnson syndrome or toxic epidermal necrolysis, which can be life-threatening. Let your doctor know immediately if you notice a rash, blisters, peeling skin, or other unusual skin changes.

Side Effects

The most common side effects reported with Cardizem LA include swelling in the lower limbs, dizziness, fatigue, and slow heart rate. Some patients also experienced rash, sinus congestion, and first-degree heart block. These side effects were generally mild and occurred more often at higher doses. Cough was also noted in a small percentage of patients.

Less common side effects include gastrointestinal issues like constipation, dry mouth, or nausea, and nervous system effects such as insomnia, tremor, or abnormal dreams. Rare but serious reactions have been reported, including liver problems, severe skin reactions, and low blood counts. Postmarketing reports also include allergic reactions, photosensitivity, and muscle or eye problems. If you notice unusual symptoms, especially rash, swelling, or dizziness, contact your healthcare provider or seek immediate medical attention.

References

1. Cardizem LA (Diltiazem) Product Monograph. Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2016.
2. Cardizem LA (Diltiazem) Drug Label Information. Bridgewater, NJ: Bausch Health US, LLC; 2019.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....