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| Strength | Pack Size | Qty | |
|---|---|---|---|
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Strength
20mg
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Cotellic (cobimetinib) is a medication prescribed to adults for treating unresectable or metastatic melanoma or histiocytic neoplasms.
Cotellic comes in 20 mg tablets for oral administration.
| Fact Table | |
|---|---|
| Formula | C21H21F3IN3O2 |
| License | FDA approved |
| Bioavailability | 45% |
| Legal status | Prescription only |
| Chemical Name | (2E)-2-[6-(4,4,4-Trifluorobutoxy)-1,3-benzodioxol-5-ylidene]-6-iodo-3,3-dimethyl-3H-indol-1-amine |
| Elimination half-life | Approximately 43.6 hours |
| Dosage (Strength) | 20 mg tablets |
| Pregnancy | Not recommended; consult a healthcare provider |
| Brands | Cotellic |
| Protein binding | 95% |
| PubChem CID | 49868015 |
| MedlinePlus | a615032 |
| ChEBI | 90940 |
| ATC code | L01XE38 |
| DrugBank | DB05771 |
| KEGG | D10364 |
| Routes of administration | Oral |
Cotellic should be taken as directed by your doctor, who will determine an appropriate Cotellic dosage.
Store Cotellic tablets below 30oC (86oF) and out of reach of children.
Carefully read the information leaflet that accompanies your Cotellic prescription for further instructions for use.
Any questions or concerns you have may be referred to your doctor or pharmacist.
Cobimetinib is the active ingredient in Cotellic.
Microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol 3350, and talc are the inactive ingredients included.
Cotellic does not have any contraindications per the most recent Prescribing Information.
Cotellic side effects in patients with unresectable or metastatic melanoma include but are not limited to diarrhea, photosensitivity, nausea, fever, vomiting, abnormal labs (increased GGT, CPK, and liver enzymes and decreased phosphorus, sodium, and lymphocytes).
Cotellic side effects in patients with histiocytic neoplasms include but are not limited to acne, skin conditions, diarrhea, infection, fatigue, nausea, swelling, dry skin, skin rash, itching, indigestion, vomiting, shortness of breath, urinary tract infections, anemia, and abnormal labs (decreased sodium, potassium, calcium, lymphocytes, and leukocytes and increased CPK, creatinine, and liver enzymes).
Contact your doctor right away if you have bothersome or persistent side effects.
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