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| Strength | Pack Size | Qty | |
|---|---|---|---|
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Strength
186mg (as 100mg Isavuconazole)
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
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Cresemba is prescribed to people who are 6+ years of age and weigh 16+ kg with invasive aspergillosis or invasive mucormycosis, which are certain types of fungal infections.
Cresemba comes in capsules that contain 74.5 mg of isavuconazonium sulfate (equivalent to 40 mg of isavuconazole) or 186 mg of isavuconazonium sulfate (equivalent to 100 mg of isavuconazole). The capsules should be taken by mouth.
Isavuconazonium sulfate is Cresemba’s generic name.
| Fact Table | |
|---|---|
| Formula | C35H42F2N8O10S (Isavuconazonium sulfate) |
| License | FDA approved |
| Bioavailability | Nearly 100% (oral and intravenous administration) |
| Legal status | Prescription only |
| Chemical Name | (2R,3S)-3-(4-cyanophenyl)-2-[(1R,2R)-1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethoxy]tetrahydrofuran-3-carboxylic acid (4S)-4-[(2R,3R)-2-(acetyloxy)-3-methoxy-3-(1H-1,2,4-triazol-1-yl)propyl]-1-[2-(methylsulfanyl)ethyl]-1,4-diazepan-1-yl ester, sulfate |
| Elimination half-life | Approximately 130 hours |
| Dosage (Strength) | 186 mg capsules (equivalent to 100 mg of isavuconazole); 372 mg powder for injection (equivalent to 200 mg of isavuconazole) |
| Pregnancy | Not recommended; consult a healthcare provider |
| Brands | Cresemba |
| Protein binding | 98% |
| PubChem CID | 54767906 |
| MedlinePlus | a615026 |
| ChEBI | 85236 |
| ATC code | J02AC05 |
| DrugBank | DB06691 |
| KEGG | D10330 |
| Routes of administration | Oral, Intravenous |
Cresemba should be taken as directed by the prescribing doctor.
Cresemba capsules should be stored in their original packaging between 20°C to 25°C (68°F to 77°F). Keep out of children’s reach.
Carefully read the information leaflet that is supplied with the Cresemba prescription for further instructions for use.
You may refer any questions or concerns to your or your child’s doctor or pharmacist.
Isavuconazonium sulfate is the active ingredient in Cresemba.
Black iron oxide, colloidal silicon dioxide, disodium edetate, gellan gum, hypromellose, magnesium citrate, microcrystalline cellulose, potassium acetate, potassium hydroxide, propylene glycol, purified water, red iron oxide, shellac, sodium lauryl sulfate, stearic acid, strong ammonia solution, talc, and titanium dioxide are the inactive ingredients in the 74.5 mg capsules.
Black iron oxide, colloidal silicon dioxide, disodium edetate, gellan gum, hypromellose, magnesium citrate, microcrystalline cellulose, potassium acetate, potassium hydroxide, propylene glycol, purified water, red iron oxide, shellac, sodium lauryl sulfate, stearic acid, strong ammonia solution, talc, and titanium dioxide are the inactive ingredients in the 186 mg capsules.
Cresemba should not be prescribed to patients who meet any of the following criteria:
Cresemba side effects in adults include but are not limited to nausea, vomiting, diarrhea, headache, elevated liver enzymes, low potassium levels in the blood, constipation, shortness of breath, cough, swelling, and back pain.
Cresemba side effects in pediatric patients include but are not limited to diarrhea, abdominal pain, vomiting, elevated liver enzymes, rash, nausea, itching, and headache.
Call a doctor right away if you or your child experiences bothersome or persistent side effects.
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Cresemba. Northbrook, IL: Astellas Pharma US, Inc.; 2023.
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