Crysvita (Burosumab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
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  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Crysvita, also called Burosumab, is a medication designed for people with certain rare diseases that affect bone growth and strength. It works by targeting a specific protein in the body known as fibroblast growth factor 23 (FGF23). By blocking FGF23, Crysvita helps the body hold onto more phosphorus, which is important for keeping bones healthy. Doctors usually prescribe this medicine for conditions like X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO). These conditions can make it difficult for bones to develop properly.

Fact Table

Formula

C6332H9792N1700O1992S42

License

US FDA, EMA

Bioavailability

~60% (subcutaneous)

Legal status

Prescription only (Rx)

Chemical Name

Burosumab

Elimination half-life

16-19 days

Dosage (Strength)

10 mg/mL, 20 mg/mL, 30 mg/mL solution for injection

Pregnancy

Consult a doctor (No adequate data)

Brands

Crysvita

Protein binding

Not available (expected to be high)

PubChem CID

122878594

MedlinePlus

a618056

ChEBI

Not available

ATC code

M05BX05

DrugBank

DB13977

KEGG

D11021

Routes of administration

Subcutaneous

Directions

The frequency and dosage of Crysvita vary based on the condition being treated and the patient's weight. Typically, the starting dose for adults is administered once every four weeks, whereas children often have it once every two weeks. The exact dosage is calculated based on the person’s body weight.

Ingredients

Burosumab is the active ingredient in Crysvita.

Contraindications

Avoid using Crysvita if any of the following apply:

  • You are taking phosphate supplements or vitamin D medications
  • Your phosphorus levels are normal or higher than normal for your age
  • You have serious kidney issues or are in the final stage of kidney disease

Cautions

  • Before beginning treatment with Crysvita, make sure to disclose the following to your healthcare provider:
    • Any existing health conditions
    • Known allergies
    • A complete list of medications you are currently using
    • Your status regarding pregnancy or breastfeeding
  • If you develop reactions like rash or hives from Crysvita, stop using it immediately and seek medical assistance.
  • Crysvita can increase phosphorus levels, which may lead to conditions like nephrocalcinosis. If your phosphorus levels get too high, your doctor might need to adjust or pause your dosage.
  • The injection site might react negatively to Crysvita. If the reaction is severe, discontinue use and get medical help.

Side Effects

Common side effects of Crysvita injections include fever, cough, vomiting, headache, and pain in the extremities. Injection site reactions such as redness, swelling, or pain are also common. Some children might experience dental problems like tooth abscesses or cavities. These side effects are generally manageable and reflect the body's response to the medication.

More serious problems with Crysvita may include hypersensitivity reactions, which may develop as rashes or more severe skin reactions, and complications from elevated blood phosphate levels that might lead to conditions like nephrocalcinosis. If you experience any signs of severe allergic reactions, worsening skin conditions, or disturbances in phosphate levels, it's important to contact your healthcare provider immediately.

References

  1. Crysvita (Burosumab) Product Monograph. Bedminster, NJ: Kyowa Kirin, Inc.; 2020.
  2. Crysvita (Burosumab) Drug Label Information. Bedminster, NJ: Kyowa Kirin, Inc.; 2023.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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