Dibenzyline (Phenoxybenzamine)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
10mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
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  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Your doctor may prescribe Dibenzyline to treat several conditions, including paroxysmal hypertension or sweating from pheochromocytoma, a rare tumor of the adrenal gland.

Dibenzyline is a non-selective alpha-adrenergic antagonist that works by blocking alpha-adrenergic receptors. This prevents norepinephrine (a hormone that constricts blood vessels) from binding to these receptors. This action relaxes blood vessels, leading to lowered blood pressure and reduced sweating.

Fact Table
Formula C18H22ClNO
License FDA approved
Bioavailability Approximately 20-30%
Legal status Prescription only
Chemical Name N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine
Elimination half-life Approximately 24 hours
Dosage (Strength) 10 mg capsules
Pregnancy Category C; consult a healthcare provider
Brands Dibenzyline
Protein binding Not specifically determined
PubChem CID 8241
MedlinePlus a682221
ChEBI 27925
ATC code C04AX02
DrugBank DB00925
KEGG D08373
Routes of administration Oral

Directions

The usual starting dosage is 10 mg by mouth twice daily. Your doctor may increase the dosage based on effect to 20-40 mg by mouth to two to three times daily.

Dibenzyline may be taken with or without food.

Ingredients

The active ingredient in Dibenzyline is phenoxybenzamine.

Interactions

The most common drug-drug interactions may include:

  • Acebutolol
  • Alprenolol
  • Asenapine
  • Atenolol
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bucindolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Dilevalol
  • Esmolol
  • Labetalol
  • Levobunolol
  • Mepindolol
  • Melphalan
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Propranolol
  • Silodosin
  • Sotalol
  • Tadalafil
  • Talinolol
  • Tamsulosin
  • Tertatolol
  • Timolol
  • Vardenafil

Cautions

Dibenzyline should be used with caution if you have a history of cardiovascular disease, renal impairment, or conditions that affect blood pressure regulation. Tell your doctor if you have a history of arteriosclerosis (blocked arteries) in cerebral or coronary arteries.

Dibenzyline can cause significant drops in blood pressure, especially upon standing (orthostatic hypotension), leading to dizziness or fainting. Slowly rise from sitting or lying to reduce the risk of these effects.

Regular monitoring of blood pressure and other vital signs is essential during treatment with phenoxybenzamine.

It is not recommended to use this drug long-term because there are case reports of carcinogenesis and mutagenesis in human patients with long-term treatment.

Side Effects

The most common side effects of Dibenzyline may include:

  • Absence of ejaculation
  • Dizziness
  • Fatigue
  • Hypotension
  • Miosis
  • Nasal congestion
  • Nausea
  • Seizure (serious)
  • Sedated
  • Somnolence
  • Tachyarrhythmia
  • Vomiting
  • Xerostomia

References

Dibenzyline [package insert].Oakville, Ontario: WellSpring; March 2008.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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