Dostinex (Cabergoline)

Prescription medicineOnly Available By Prescription
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0.5mg
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1mg
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0.25mg
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0.5mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Your doctor may prescribe Dostinex for conditions associated with prolactin excess, providing symptomatic relief and improving reproductive health in affected individuals. Close monitoring for potential side effects and drug interactions is essential to ensure safe and appropriate use of this medication.

Cabergoline is prescribed primarily to treat disorders associated with high levels of prolactin hormone secretion, such as hyperprolactinemia and prolactin-secreting pituitary adenomas (prolactinomas). It can also be used to suppress lactation after childbirth. Cabergoline stimulates dopamine receptors in the brain, inhibiting prolactin production and release from the pituitary gland, restoring hormonal balance.

Prolactin is a hormone produced naturally by the pituitary gland. It regulates breast development, lactation, and many other bodily processes. High levels of prolactin are normal during pregnancy and lactation, but high levels at other times may be a sign of a medical condition.

Fact Table
Formula C26H37N5O2
License FDA approved
Bioavailability Approximately 60-70%
Legal status Prescription only
Chemical Name 1-[(6-Allylergolin-8ß-yl)-carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
Elimination half-life Approximately 63-68 hours (may vary widely)
Dosage (Strength) 0.5 mg tablets
Pregnancy Category B; consult a healthcare provider
Brands Dostinex
Protein binding 41-42%
PubChem CID 177056
MedlinePlus a699051
ChEBI 8285
ATC code G02CB03
DrugBank DB00248
KEGG D00936
Routes of administration Oral

Directions

For conditions of high prolactin, the usual dosage is Dostinex 0.25 mg twice weekly, which can be increased to a maximum of 1 mg twice weekly.

For lactation suppression, the usual dosage is 1 mg given within 24-72 hours after delivery.

Ingredients

The active ingredient in Dostinex is cabergoline.

Interactions

The most common drug-drug interactions are:

  • Haloperidol
  • Itraconazole
  • Metoclopramide
  • Olanzapine
  • Sulpiride

Cautions

Tell your doctor if you have a history of cardiovascular disease, psychiatric disorders, or liver impairment. It may cause dizziness or fainting, particularly when standing up from a sitting or lying position.

Use caution with activities that require mental alertness until you know how Dostinex affects you.

Regular liver and cardiac function monitoring is recommended during treatment with Dostinex.

Side Effects

Common adverse reactions include:

  • Congestive heart failure
  • Disorder of pericardium
  • Heart valve disorder
  • Constipation
  • Nausea
  • Retroperitoneal fibrosis
  • Dizziness
  • Headache
  • Fatigue
  • Fibrosis of pleura
  • Pleural effusion
  • Pulmonary fibrosis

References

Dostinex [package insert]. New York, NY: Pfizer; July 2011.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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