DuoCort (Hydrocortisone)

Prescription medicineOnly Available By Prescription
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

DuoCort is a prescription medication primarily used to treat many conditions, primarily adrenal insufficiency. People with this condition have adrenal glands that do not produce adequate amounts of certain steroid hormones, particularly cortisol.

Adrenal insufficiency can lead to various symptoms, including tiredness, muscle weakness, weight loss, and hypotension. Hydrocortisone, the active ingredient in DuoCort, is a corticosteroid that mimics the action of cortisol, helping to regulate essential body functions and maintain metabolic stability.

Fact Table
Formula C21H30O5
License FDA approved
Bioavailability Approximately 96% (oral)
Legal status Prescription only
Chemical Name (11ß)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
Elimination half-life Approximately 1.5-2 hours
Dosage (Strength) 5 mg, 10 mg, 20 mg tablets (extended-release)
Pregnancy Category C; consult a healthcare provider
Brands DuoCort, Plenadren (in some regions), Hydrocortisone
Protein binding Approximately 90%
PubChem CID 5754
MedlinePlus a682206
ChEBI 17650
ATC code H02AB09
DrugBank DB00741
KEGG D00086
Routes of administration Oral

Directions

The dosage of DuoCort is individualized to each patient based on their condition and their response to treatment.

Typically, the medication is administered orally once or twice daily, with the timing of doses designed to mimic the natural rhythm of cortisol secretion.

Ingredients

The active ingredient in DuoCort is hydrocortisone.

Interactions

Common drug-drug interactions may include:

  • Abametapir
  • Aceclofenac
  • Acemetacin
  • Aldesleukin
  • Amtolmetin Guacil
  • Aspirin
  • Atazanavir
  • Balofloxacin
  • Bemiparin
  • Besifloxacin
  • Bromfenac
  • Bufexamac
  • Bupropion
  • Carbamazepine
  • Celecoxib
  • Choline Salicylate
  • Ciprofloxacin
  • Clarithromycin
  • Clonixin
  • Cobicistat
  • Conivaptan
  • Cosyntropin
  • Darunavir
  • Desmopressin
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Enoxacin
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Fedratinib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Fleroxacin
  • Floctafenine
  • Flufenamic Acid
  • Flumequine
  • Flurbiprofen
  • Fosnetupitant
  • Gatifloxacin
  • Gemifloxacin
  • Ibuprofen
  • Indomethacin
  • Itraconazole
  • Ketoprofen
  • Ketorolac
  • Lenacapavir
  • Levofloxacin
  • Lomefloxacin
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Lutetium Lu 177 Dotatate
  • Macimorelin
  • Mavacamten
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Morniflumate
  • Moxifloxacin
  • Nabumetone
  • Nadifloxacin
  • Nadroparin
  • Naproxen
  • Nepafenac
  • Netupitant
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Norfloxacin
  • Ofloxacin
  • Omaveloxolone
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pazufloxacin
  • Pefloxacin
  • Phenobarbital
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranoprofen
  • Primidone
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Prulifloxacin
  • Rofecoxib
  • Rufloxacin
  • Salicylic Acid
  • Salsalate
  • Sargramostim
  • Sodium Salicylate
  • Somatrogon-ghla
  • Sparfloxacin
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Tosufloxacin
  • Upadacitinib
  • Valdecoxib

Cautions

Before starting DuoCort, tell your doctor if you have a history of infections, high blood pressure, diabetes, osteoporosis, or gastrointestinal issues.

Long-term use of corticosteroids can lead to side effects such as weakened immune response, increased blood sugar levels, and bone density loss. Regular monitoring by a healthcare provider is essential to manage these risks.

Side Effects

The most common side effects may include:

  • Altered behavior
  • Body fluid retention
  • Cataract
  • Crisis
  • Cushing's syndrome
  • Delirium
  • Depressed mood
  • Disturbance in mood
  • Euphoria
  • Glaucoma
  • Growth retardation
  • Hyperglycemia
  • Impaired glucose tolerance
  • Increased appetite
  • Increased blood pressure
  • Mania
  • Osteoporosis
  • Pheochromocytoma
  • Psychotic disorder
  • Pulmonary tuberculosis
  • Weight gain
  • With hallucinations
  • At increased risk for infection

References

Cortef (hydrocortisone oral) [package insert]. New York, NY: Pfizer; November 2019.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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