Edecrin (Ethacrynic Acid)

Description

Edecrin (Ethacrynic Acid) is a medication that helps the body get rid of extra fluid, a condition known as edema. This fluid buildup can happen because of heart problems, liver issues, or kidney failure. Edecrin works by making you urinate more, which helps remove the excess fluid. Unlike some other loop diuretics, Ethacrynic Acid does not contain sulfonamide groups, making it appropriate for those with sulfa allergies. By acting on the kidneys, Edecrin helps the body get rid of sodium, chloride, and water, which helps reduce swelling.

Directions

Ethacrynic acid is usually taken by mouth. It’s important to closely follow the instructions on the prescription label and stick to the dosing schedule given by a doctor. The Edecrin dosage may need to be changed based on the response to the medication and a person’s overall health condition. For most people, the starting dose is between 50 mg and 200 mg per day, and this amount can be divided into several smaller doses.

Ingredients

The active ingredient in Edecrin is Ethacrynic Acid.

Contraindications

Avoid taking or using this medication if any of the following apply:

• Hypersensitivity to Ethacrynic Acid
• Presence of anuria (lack of urine production)
• Severe cases of watery diarrhea
• Infants require careful consideration and medical advice

Cautions

• Before starting treatment with Edecrin, tell your healthcare provider if you have:
• Any existing health conditions
• Any allergies
• A list of all medications you are currently taking
• Whether you are pregnant or breastfeeding

• Edecrin is a medication that can cause significant loss of fluids and important minerals in the body. To prevent these problems, it's important to regularly check weight and adjust the dosage as needed. If there are signs of too much fluid loss or low mineral levels, the medication should be stopped or the dose changed.
• For patients with liver problems and fluid buildup (ascites), starting Edecrin in a hospital is recommended. This allows for close monitoring of any complications, such as imbalances in minerals or brain issues.
• Using Edecrin too quickly or in large amounts can lead to low blood pressure. This is especially risky for older patients with heart issues, as it could increase the chance of blood clots or strokes. It's important to keep an eye on weight loss to avoid these complications.
• People who take heart medications like digitalis or certain steroids should be careful, as low potassium levels can lead to serious side effects. Extra potassium or medications that help retain potassium may be needed.
• Edecrin may also cause hearing problems, such as ringing in the ears, dizziness, or even hearing loss. This is more likely in people with kidney problems or if the medication is given in high doses through an IV. While hearing loss might be temporary, it could sometimes last a long time.
• People taking antibiotics that affect hearing should avoid using Edecrin at the same time, as it can increase the risk of hearing issues.
• Regular blood tests are necessary to check for mineral imbalances and kidney function, especially when starting Edecrin. If any imbalances are found, they should be corrected quickly.
• Edecrin can interact with lithium, a medication used for certain mental health conditions, raising the risk of lithium toxicity. Therefore, these two medications should generally not be combined.
• For those taking blood thinners like warfarin, it may be necessary to adjust their doses because Edecrin can make these medications stronger.
• Edecrin can also reduce how well non-steroidal anti-inflammatory drugs (NSAIDs) work. Patients using both should be monitored to ensure they still achieve the desired effects from the diuretic.
• The safety of Edecrin during pregnancy isn't fully known. It should only be used if the benefits outweigh any potential risks. Nursing mothers should talk to their doctor before using it since it's unclear if Edecrin passes into breast milk.
• The safety and effectiveness of Edecrin for infants and children have not been thoroughly studied. Parents should seek advice from a healthcare provider about using it for younger patients.
• Older adults may react more strongly to Edecrin, especially if they have kidney problems. In these cases, dosage adjustments and careful monitoring of kidney health are recommended.

Side Effects

Edecrin can cause stomach problems like nausea, vomiting, diarrhea, and discomfort, especially when taken in high doses or for a long time. Other possible side effects include headaches, fatigue, skin rashes, and hearing issues like ringing in the ears or a feeling of fullness. If these mild symptoms persist or get worse, it's important to talk to your doctor.

Serious side effects of Edecrin can include severe diarrhea, gastrointestinal bleeding, and high uric acid levels. Rarely, it may lead to serious blood problems, liver issues like jaundice, and neurological effects such as confusion. If you experience severe diarrhea, signs of bleeding, jaundice, or hearing loss, stop taking Edecrin and seek medical help right away.

References

1. Edecrin (Ethacrynic Acid) Product Monograph. Rahway, NJ: Merck & Co., Inc.; 2005.
2. Edecrin (Ethacrynic Acid) Drug Label Information. Bridgewater, NJ: Bausch Health US, LLC; 2020.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....