Also Known as Vymada
Top brand choice
Strength | Pack Size | Qty | |
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Strength
24mg/26mg
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Strength
49mg/51mg
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Strength
97mg/103mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Entresto is a prescription medication combining sacubitril and valsartan. It is designed to treat heart failure with reduced ejection fraction (HFrEF). It also combines an angiotensin receptor-neprilysin inhibitor (ARNI) and an angiotensin II receptor blocker.
It prevents the activity of angiotensin II and neprilysin, an enzyme that degrades beneficial peptides. By blocking these pathways, Entresto helps to relax blood vessels and reduce the strain on the heart, ultimately improving heart function and reducing the risk of cardiovascular events.
Fact Table |
|
Formula |
C96H120N12Na6O21 |
License |
EU EMA |
Bioavailability |
60% |
Legal status |
US: RX Only |
Chemical Name |
Sacubitril / Valsartan |
Elimination half-life |
1.4-11 hours |
Dosage (Strength) |
24/25mg (56 or 168 tablets), 49/51mg (56 or 168 tablets), 97/103mg (56 or 168 tablets) |
Pregnancy |
Consult a doctor |
Brands |
Entresto |
Protein binding |
97% |
PubChem CID |
71449007 |
MedlinePlus |
a682462 |
ChEBI |
- |
ATC code |
C09DX04 |
DrugBank |
DB09292, DB00177 |
KEGG |
D10226 |
Routes of administration |
By mouth (tablets) |
For adults, the starting dosage is 49/51 mg by mouth twice daily.
Your doctor may adjust the dosage every two weeks to reach the target dose. The dosage may be increased to 97/103 mg by mouth twice daily.
The active ingredients in Entresto are sacubitril and valsartan.
The most common drug-drug interactions may include:
Tell your doctor if you have a history of angioedema, severe kidney disease, or are pregnant, as you should use Entresto with caution.
Entresto may also increase the risk of hyperkalemia (high potassium levels) and hypotension (low blood pressure).
Common adverse reactions to this drug include:
Entrestro [package insert]. East Hanover, NJ: Novartis; February 2021.
What is Entresto used for?
Entresto treats chronic heart failure, reducing death and hospitalization risk by helping the heart pump better.
What drugs should not be taken with Entresto?
Avoid ACE inhibitors, ARBs, aliskiren, meds raising potassium levels, NSAIDs, and lithium with Entresto to prevent complications.
Does Entresto lower blood pressure?
Yes, by relaxing blood vessels and reducing fluid retention, but effects may vary. Follow doctor's advice.
What are the most common side effects of Entresto?
Low blood pressure, high potassium, cough, dizziness, kidney problems.
Do Entresto side effects go away?
Most common side effects of Entresto usually resolve within a day of stopping. Severe issues may need medical care but are often corrected quickly.
How does Entresto work?
It relaxes blood vessels and reduces heart strain.
How long does it take for Entresto to work?
Typically, Entresto shows effects within a few weeks, though responses vary.
What happens if you suddenly stop taking Entresto?
Stopping suddenly can worsen heart failure symptoms. Always follow your doctor’s guidance.
What happens if you take a double dose of Entresto?
Doubling Entresto can up the risk of side effects. Notify your doctor if this happens.
Can Entresto be taken once a day?
Entresto is generally prescribed for twice-daily dosing, but it's crucial to consult your doctor to confirm the appropriate dosing regimen for your specific situation.