Entresto (Sacubitril/Valsartan)

Also Known as Vymada

Prescription medicineOnly Available By Prescription
Sezzle

Top brand choice

Strength Pack Size Qty
Strength
24mg/26mg
Pack Size
Qty
Strength
49mg/51mg
Pack Size
Qty
Strength
97mg/103mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
Strength
24mg/26mg
Pack Size
Qty
Strength
49mg/51mg
Pack Size
Qty
Strength
97mg/103mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Entresto is a prescription medication combining sacubitril and valsartan. It is designed to treat heart failure with reduced ejection fraction (HFrEF). It also combines an angiotensin receptor-neprilysin inhibitor (ARNI) and an angiotensin II receptor blocker.

It prevents the activity of angiotensin II and neprilysin, an enzyme that degrades beneficial peptides. By blocking these pathways, Entresto helps to relax blood vessels and reduce the strain on the heart, ultimately improving heart function and reducing the risk of cardiovascular events.

Fact Table

Formula

C96H120N12Na6O21

License

EU EMA

Bioavailability

60%

Legal status

US: RX Only

Chemical Name

Sacubitril / Valsartan

Elimination half-life

1.4-11 hours

Dosage (Strength)

24/25mg (56 or 168 tablets), 49/51mg (56 or 168 tablets), 97/103mg (56 or 168 tablets)

Pregnancy

Consult a doctor

Brands

Entresto

Protein binding

97%

PubChem CID

71449007

MedlinePlus

a682462

ChEBI

-

ATC code

C09DX04

DrugBank

DB09292, DB00177

KEGG

D10226

Routes of administration

By mouth (tablets)

Directions

For adults, the starting dosage is 49/51 mg by mouth twice daily.

Your doctor may adjust the dosage every two weeks to reach the target dose. The dosage may be increased to 97/103 mg by mouth twice daily.

Ingredients

The active ingredients in Entresto are sacubitril and valsartan.

Interactions

The most common drug-drug interactions may include:

  • Aceclofenac
  • Acemetacin
  • Amtolmetin Guacil
  • Aliskiren
  • Asciminib
  • Benazepril
  • Bromfenac
  • Bufexamac
  • Captopril
  • Celecoxib
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Enalapril
  • Enalaprilat
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fosinopril
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Furosemide
  • Ibuprofen
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Lisinopril
  • Lithium
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Potassium Citrate
  • Potassium Phosphate
  • Pranoprofen
  • Propionic Acid
  • Propyphenazone
  • Proglumetacin
  • Propionic Acid
  • Proquazone
  • Quinapril
  • Ramipril
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Simeprevir
  • Sodium Salicylate
  • Spirapril
  • Sulindac
  • Tacrolimus
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Trandolapril
  • Trimethoprim
  • Valdecoxib
  • Zofenopril

Cautions

Tell your doctor if you have a history of angioedema, severe kidney disease, or are pregnant, as you should use Entresto with caution.

Entresto may also increase the risk of hyperkalemia (high potassium levels) and hypotension (low blood pressure).

Side Effects

Common adverse reactions to this drug include:

  • Angioedema
  • Dizziness
  • Hyperkalemia
  • Hypotension
  • Renal failure

References

Entrestro [package insert]. East Hanover, NJ: Novartis; February 2021.



Frequently Asked Questions about Entresto


What is Entresto used for?

Entresto treats chronic heart failure, reducing death and hospitalization risk by helping the heart pump better.


What drugs should not be taken with Entresto?

Avoid ACE inhibitors, ARBs, aliskiren, meds raising potassium levels, NSAIDs, and lithium with Entresto to prevent complications.


Does Entresto lower blood pressure?

Yes, by relaxing blood vessels and reducing fluid retention, but effects may vary. Follow doctor's advice.


What are the most common side effects of Entresto?

Low blood pressure, high potassium, cough, dizziness, kidney problems.


Do Entresto side effects go away?

Most common side effects of Entresto usually resolve within a day of stopping. Severe issues may need medical care but are often corrected quickly.


How does Entresto work?

It relaxes blood vessels and reduces heart strain.


How long does it take for Entresto to work?

Typically, Entresto shows effects within a few weeks, though responses vary.


What happens if you suddenly stop taking Entresto?

Stopping suddenly can worsen heart failure symptoms. Always follow your doctor’s guidance.


What happens if you take a double dose of Entresto?

Doubling Entresto can up the risk of side effects. Notify your doctor if this happens.


Can Entresto be taken once a day?

Entresto is generally prescribed for twice-daily dosing, but it's crucial to consult your doctor to confirm the appropriate dosing regimen for your specific situation.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews