Also Known as Oestrogel
Only Available By Prescription
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Strength
0.06% Gel
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EstroGel 0.06% (estradiol gel) is a topical estrogen gel used to treat symptoms of menopause and vuvlar and vaginal atrophy associated with menopause.
Carefully read the information and follow the instructions that come with your EstroGel prescription. Refer any questions or concerns to your doctor or pharmacist.
EstroGel is available in a 50 gram metered-dose pump. Before using EstroGel for the first time, you need to prime the pump by pressing the pump 5 times. Throw the unused gel in the trash or rinse it down the sink.
One pump depression of EstroGel should be applied to the arm once daily. Apply a thin layer of the gel on the inside and outside of the entire arm, from the wrist to the shoulder. One pump depression delivers 1.25 grams of gel that contains 0.75 mg of estradiol. Wash your hands with soap and water after each use.
Keep away from children. Store at 20°C to 25°C (68° to 77°F).
EstroGel contains estradiol. The base is made of a hydroalcoholic gel that's absorbed. Other components of the gel include purified water, alcohol, triethanolamine, and carbomer 934P.
Avoid using Estrogel if you:
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WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA See full prescribing information for complete boxed warning Estrogen-Alone Therapy
Estrogen Plus Progestin Therapy
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WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA Estrogen-Alone Therapy Endometrial Cancer There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding. Cardiovascular Disorders and Probable Dementia Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia. The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg]-alone, relative to placebo. The WHI Memory Study (WHIMS) estrogen-alone ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with CE (0.625 mg)-alone, relative to placebo. It is unknown whether this finding applies to younger postmenopausal women. In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and other dosage forms of estrogens. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. Estrogen Plus Progestin Therapy Cardiovascular Disorders and Probable Dementia Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. The WHI estrogen plus progestin substudy reported increased risks of DVT, pulmonary emboli (PE), stroke and myocardial infarction (MI) in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral CE (0.625 mg) combined with medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo. The WHIMS estrogen plus progestin ancillary study of the WHI reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with daily CE (0.625 mg) plus MPA (2.5 mg), relative to placebo. It is unknown whether this finding applies to younger postmenopausal women. Breast Cancer The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer. In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA, and other combinations and dosage forms of estrogens and progestins. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. |
EstroGel side effects include endometrial cancer, breast cancer, breast pain, breast tenderness, blood clots in the legs, certain heart problems, vein inflammation, nausea, abdominal distension, diarrhea, stomach discomfort, hair loss, skin conditions, vision problems, headache, dizziness, trouble sleeping, numbness, loss of the ability to communicate, slowness of thought, and tingling or prickling sensation. If you experience bothersome or continuous side effects, call your doctor right away.
Looking for a low EstroGel price? You can buy EstroGel at a competitive cost online and with a valid prescription from your doctor at Canada Drugs Direct.
EstroGel 0.06% (estradiol gel) for topical use. Herndon, VA: ASCEND Therapeutics US, LLC; 2020.
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