Evamist (Estradiol)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
1.53mg/spray 8.1ml
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Your doctor may prescribe Evamist for the treatment of symptoms associated with menopause. During menopause, estrogen decreases, leading to symptoms like hot flashes and vaginal dryness

Estrogen is essential for many body processes and helps to alleviate the discomforts associated with menopause by replenishing the reduced levels of estrogen in the body. Evamist is administered as a transdermal spray, allowing the hormone to be absorbed through the skin into the bloodstream.

Fact Table
Formula C18H24O2
License FDA approved
Bioavailability Approximately 5% (transdermal spray)
Legal status Prescription only
Chemical Name (17ß)-estra-1,3,5(10)-triene-3,17-diol
Elimination half-life Approximately 36 hours (transdermal)
Dosage (Strength) 1.53 mg/spray
Pregnancy Not for use in pregnancy
Brands Evamist
Protein binding Approximately 95-98%
PubChem CID 5757
MedlinePlus a682922
ChEBI 16469
ATC code G03CA03
DrugBank DB00783
KEGG D00116
Routes of administration Transdermal (spray)

Directions

Apply one spray to the forearm once daily. Do not stop this medication without speaking to your healthcare provider.

Ingredients

The active ingredient in Evamist is estradiol.

Interactions

Common drug-drug interactions may include:

  • Abametapir
  • Amifampridine
  • Amoxicillin
  • Ampicillin
  • Amprenavir
  • Apalutamide
  • Aprepitant
  • Armodafinil
  • Artemether
  • Bacampicillin
  • Belzutifan
  • Betamethasone
  • Bexarotene
  • Bosentan
  • Bupropion
  • Carbamazepine
  • Carbenicillin
  • Cefaclor
  • Cefadroxil
  • Cefdinir
  • Cefditoren
  • Cefixime
  • Cefpodoxime
  • Cefprozil
  • Ceftazidime
  • Ceftibuten
  • Cefuroxime
  • Cenobamate
  • Ceritinib
  • Clarithromycin
  • Clobazam
  • Cloxacillin
  • Colesevelam
  • Conivaptan
  • Cosyntropin
  • Cyclacillin
  • Cyclosporine
  • Dabrafenib
  • Darunavir
  • Dexamethasone
  • Dicloxacillin
  • Donepezil
  • Doxycycline
  • Efavirenz
  • Elafibranor
  • Elagolix
  • Elvitegravir
  • Enasidenib
  • Encorafenib
  • Enzalutamide
  • Eslicarbazepine Acetate
  • Etravirine
  • Fedratinib
  • Fexinidazole
  • Fezolinetant
  • Fosamprenavir
  • Fosaprepitant
  • Fosnetupitant
  • Fosphenytoin
  • Griseofulvin
  • Guar Gum
  • Isotretinoin
  • Itraconazole
  • Ivosidenib
  • Lesinurad
  • Lixisenatide
  • Lorlatinib
  • Lumacaftor
  • Mavacamten
  • Meropenem
  • Minocycline
  • Mitapivat
  • Mitotane
  • Mobocertinib
  • Modafinil
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nafcillin
  • Nelfinavir
  • Netupitant
  • Nevirapine
  • Octreotide
  • Oxacillin
  • Oxcarbazepine
  • Oxytetracycline
  • Penicillin G
  • Penicillin G Procaine
  • Penicillin V
  • Phenobarbital
  • Phenylbutazone
  • Phenytoin
  • Pitolisant
  • Pixantrone
  • Prednisolone
  • Prednisone
  • Primidone
  • Repotrectinib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Secobarbital
  • Somatrogon-ghla
  • St John's Wort
  • Sugammadex
  • Sultamicillin
  • Tazemetostat
  • Telaprevir
  • Tetracycline
  • Theophylline
  • Ticarcillin
  • Tigecycline
  • Tirzepatide
  • Topiramate
  • Tovorafenib
  • Tranexamic Acid
  • Ulipristal
  • Valproic Acid

Cautions

Evamist should not be used during pregnancy or while breastfeeding.

Before starting Evamist, it is important to inform your healthcare provider if you have a history of heart disease, liver disease, kidney disease, breast cancer, or any hormone-sensitive conditions.

Side Effects

Common side effects of this drug can include:

  • Abdominal bloating
  • Abdominal pain
  • Application site irritation
  • Breast tenderness
  • Chloasma
  • Disorder of menstruation
  • Edema
  • Headache
  • Hirsutism
  • Loss of scalp hair
  • Persistent erythema of skin
  • Pain
  • Pain of breast
  • Pruritus
  • Swelling of breast
  • Upper respiratory infection
  • Vaginal discomfort
  • Weight increased
  • Withdrawal bleeding

References

Evamist [package insert]. City, ST: Pharma; April 2008.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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