Flolan (Epoprostenol)

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To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Your doctor may prescribe Flolan to manage pulmonary arterial hypertension (PAH), which is when there is elevated blood pressure in the lungs' arteries. PAH can lead to symptoms such as dyspea, dizziness, and heart failure.

Epoprostenol works by relaxing the blood vessels in the lungs, reducing the heart's workload, and improving blood flow. This action helps to relieve the symptoms of PAH and improve the quality of life.

Fact Table
Formula C20H32O5
License FDA approved
Bioavailability Not applicable (administered intravenously)
Legal status Prescription only
Chemical Name (5Z,9a,11a,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid
Elimination half-life Approximately 6 minutes
Dosage (Strength) Available as powder for injection: 0.5 mg and 1.5 mg vials
Pregnancy Category B; consult a healthcare provider
Brands Flolan, Veletri
Protein binding 81%
PubChem CID 5280723
MedlinePlus a601121
ChEBI 31677
ATC code B01AC09
DrugBank DB01240
KEGG D07961
Routes of administration Intravenous

Directions

The dosage and infusion rate are determined by the doctor based on the patient's specific condition, response to treatment, and other factors.

Flolan is administered through continuous intravenous infusion using a portable infusion pump, and training from a healthcare provider is required before starting the treatment.

Regular follow-up appointments are necessary to monitor the treatment's effectiveness and adjust the dosage as required.

Ingredients

The active ingredient in Flolan is epoprostenol.

Interactions

Common drug-drug interactions with this medication include:

  • Abrocitinib
  • Aceclofenac
  • Acemetacin
  • Amtolmetin Guacil
  • Apixaban
  • Argatroban
  • Betrixaban
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Caplacizumab-yhdp
  • Celecoxib
  • Choline Salicylate
  • Citalopram
  • Clonixin
  • Clopidogrel
  • Dabigatran Etexilate
  • Danaparoid
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Escitalopram
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Heparin
  • Ibuprofen
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Lepirudin
  • Levoketoconazole
  • Levomilnacipran
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Methotrexate
  • Milnacipran
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Paroxetine
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sertraline
  • Sodium Salicylate
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Valdecoxib
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin

Cautions

Tell your doctor if you are pregnant or breastfeeding before starting this drug.

Flolan can increase the risk of bleeding, so patients should avoid activities that may cause injury.

Discuss any pre-existing medical conditions with your healthcare provider. Those with a history of heart disease, bleeding disorders, or liver and kidney issues should exercise caution when using this medication.

Side Effects

Common side effects may include:

  • Abdominal pain
  • Anxiety
  • Arthralgia
  • Bloodstream infection
  • Bradyarrhythmia
  • Chest pain
  • Diarrhea
  • Dizziness
  • Feeling nervous
  • Flushing
  • Headache
  • Hemorrhage
  • Hypersplenism
  • Hypotension
  • Influenza-like illness
  • Jaw pain
  • Loss of appetite
  • Musculoskeletal pain
  • Nausea and vomiting
  • Sepsis
  • Splenomegaly
  • Tachycardia

References

Flolan [package insert]. Research Triangle Park, NC: GlaxoSmithKline; January 2008.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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