Harvoni (Ledipasvir/Sofosbuvir)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Strength
90mg/400mg
Pack Size
Qty

Top Generic choice

Strength Pack Size Qty
Strength
90mg/400mg
Pack Size
Qty
What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Harvoni (ledipasvir/sofosbuvir) is a combination of drugs used to treat Hepatitis C infection. The two medications in Harvoni disrupt the replication processes of the Hepatitis C virus in complementary ways. Harvoni comes as a brand name product as well as a Harvoni generic product. You can buy Harvoni online as a 45mg/200mg or 90/400mg tablet. Store your Harvoni and Harvoni generic at room temperature and keep it out of reach of children.

Fact Table

Formula

C49H54F2N8O8 (Ledipasvir), C22H29FN3O9P (Sofosbuvir)

License

US FDA, EMA

Bioavailability

Ledipasvir: ~76%; Sofosbuvir: ~92%

Legal status

Prescription only (Rx)

Chemical Name

Ledipasvir and Sofosbuvir

Elimination half-life

Ledipasvir: 47 hours; Sofosbuvir: 0.4 hours (parent), 27 hours (GS-331007 metabolite)

Dosage (Strength)

90 mg ledipasvir / 400 mg sofosbuvir tablet (once daily)

Pregnancy

Consult a doctor – limited human data available

Brands

Harvoni

Protein binding

Ledipasvir: ~99.8%; Sofosbuvir: ~61–65%

PubChem CID

67505836 (combo), 67505836 (Ledipasvir), 45375808 (Sofosbuvir)

MedlinePlus

a614040

ChEBI

Ledipasvir: 85081, Sofosbuvir: 85082

ATC code

J05AP51

DrugBank

DB09102 (combo), DB09027 (Ledipasvir), DB08934 (Sofosbuvir)

KEGG

D10572

Routes of administration

Oral

Directions

  • You can take Harvoni with or without food.
  • Do not use antacid products within four hours of your Harvoni dose.
  • Do not crush or chew your Harvoni tablets.
  • The usual dosing instructions for Harvoni are:
    • Take one 90mg/400mg tablet by mouth once daily for twelve weeks.
      • Your dose could be lower if you have a liver condition.
      • Your doctor could use Ribavirin in combination with Harvoni.

Ingredients

  • The active ingredients are ledipasvir and sofosbuvir
  • For a full list of inactive ingredients, see the package insert.
  • Do not use Harvoni if you have a known allergy to any of the ingredients.

Cautions

Harvoni interacts with several medications. Let your doctor know if you currently use any of the following:

Side Effects

References:

  1. DailyMed - HARVONI- ledipasvir and SOFOSBUVIR TABLET, film COATED HARVONI- ledipasvir and SOFOSBUVIR TABLET, film COATED HARVONI- ledipasvir and SOFOSBUVIR PELLET. (2020). Retrieved April 02, 2020
  2. Harvoni. (n.d.). Retrieved April 02, 2020


IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

product-reviews Product Reviews