Ibsrela (Tenapanor)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
50mg
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Ibsrela, also known as Tenapanor, is a medicine used to treat irritable bowel syndrome with constipation (IBS-C) in adults. This condition causes discomfort in the gut and makes it hard to have regular bowel movements. The Ibsrela mechanism of action involves blocking a specific protein in the gut that normally helps absorb sodium. By doing this, it allows more water to stay in the intestines, which can lead to softer stools and more frequent bowel movements.

Fact Table

Formula

C50H66F3N9O10S2

License

US FDA

Bioavailability

Minimal (local action in the gut)

Legal status

Prescription only (Rx)

Chemical Name

(2R)-2-({[(2S)-1-(2-{[2-fluoro-5-(trifluoromethyl)phenyl]sulfonyl}benzyl)pyrrolidine-2-carbonyl]amino}acetyl)amino}-3-(3-hydroxy-3-phenylpropanamido)propanoic acid

Elimination half-life

Not systemically absorbed

Dosage (Strength)

50 mg tablets

Pregnancy

Consult a doctor (No data in humans; Animal studies show some risk)

Brands

Ibsrela

Protein binding

Not applicable (acts locally in the gut)

PubChem CID

71582774

MedlinePlus

a620036

ChEBI

134713

ATC code

A06AX07

DrugBank

DB11763

KEGG

D10925

Routes of administration

Oral

Directions

Ibsrela is typically taken as a 50 mg tablet twice daily, ideally right before breakfast and dinner. It's important to adhere to this schedule for the medication to be most effective. If you miss a dose, do not double up; instead, continue with your regular dosing schedule.

Ingredients

Tenapanor is the active ingredient in Ibsrela.

Contraindications

Avoid taking or using Ibsrela if any of the following apply:

  • Individuals under the age of 6, as the effects and safety have not been established for this age group
  • People with a known or suspected mechanical gastrointestinal obstruction
  • Those with a hypersensitivity to Tenapanor or any component of the drug product

Cautions

  • Before using Ibsrela, ensure you provide your healthcare provider with the following information:
    • Existing health conditions
    • Known allergies
    • A list of all the medications you are currently taking
    • Your pregnancy or breastfeeding status
  • Do not use Ibsrela in children under 6 years old due to a high risk of serious dehydration, which can be fatal. The safety and efficacy for those under 18 have not been established.
  • Diarrhea is a frequent side effect in those treated with Ibsrela, and in some cases, it may be severe. If severe diarrhea develops, it's important to stop taking Ibsrela and rehydrate.

Side Effects

Ibsrela mainly causes diarrhea, which can occasionally be severe. Should you experience intense diarrhea, it’s recommended to stop using Ibsrela and consult your doctor. Besides diarrhea, other usual side effects include a feeling of abdominal swelling or pressure, gas, and dizziness.

If you encounter severe diarrhea or the other side effects become troublesome, it's important to reach out to your healthcare provider. Managing these side effects immediately helps maintain your health and well-being while on this medication.

References

  1. Ibsrela (Tenapanor) Product Monograph. Waltham, MA: Ardelyx, Inc,; 2022.
  2. Ibsrela (Tenapanor) Drug Label Information. Waltham, MA: Ardelyx, Inc,; 2022.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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