Imcivree (Setmelanotide)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Imcivree, known by its generic name Setmelanotide, is a medication classified as a melanocortin 4 receptor agonist. By activating these receptors, Imcivree may help reduce hunger and promote weight loss. For this reason, it is used to treat certain genetic obesity disorders resulting from gene mutations. Healthcare professionals typically prescribe it to both adults and children (ages 6 and older) who are living with conditions like proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiencies.

Directions

Imcivree is administered via a subcutaneous injection, meaning the medicine is injected under the skin. The typical recommended dosage is 3 mg once daily for people 6 years and older. However, the starting dosage may be lower and depend on the age of the person taking it.

Individuals with mild to moderate kidney problems do not require dosage adjustments. However, for people with severe renal impairment, medical professionals may recommend changes to the dosing schedule. Consult a healthcare provider for the proper dosage and instructions for using the medication.

Ingredients

The active ingredient in Imcivree is Setmelanotide. The medication may also contain inactive ingredients, such as mannitol, phenol, benzyl alcohol, and water for injection.

Contraindications

People with a known allergy or hypersensitivity to Setmelanotide or any ingredients of the medication should avoid taking it.

Cautions

  • Before starting treatment with Imcivree, consult your doctor or healthcare provider about the following:
    • Other medications you take.
    • Other medical conditions you have.
    • If you’re pregnant or breastfeeding.
  • Imcivree may cause disturbances in sexual arousal. As a male, you might experience unexpected penile erections, and as a female, you might encounter sexual adverse reactions. If you're a male and have an erection lasting more than four hours, seek emergency medical attention.
  • There's a risk of depression and suicidal ideation with Imcivree. Watch for signs of new or worsening depression or suicidal thoughts. If you experience these symptoms, especially if they are significant or persistent, talk to your healthcare provider.
  • Be aware of the risk of serious hypersensitivity reactions, including anaphylaxis. If you suspect you're having a hypersensitivity reaction, seek immediate medical attention and discontinue Imcivree.
  • Imcivree may lead to an increase in skin pigmentation and darkening of moles. A healthcare provider may recommend a full-body skin examination before and during treatment to monitor for any changes in your skin.
  • Note that Imcivree is not appropriate for neonates or infants. There may be a risk of serious adverse reactions related to the benzyl alcohol preservative in the medication, which may be fatal for newborns and low birth weight infants.

Side Effects

Imcivree carries a risk of side effects, with some being more common than others. Among the most common Imcivree side effects, people may experience injection site reactions, with symptoms like pain or irritation around the area of injection. Skin darkening or hyperpigmentation is also frequently observed. Some people report feelings of nausea, headaches, diarrhea, stomach pain, back pain, fatigue, and occasional vomiting.

While most side effects are manageable, Imcivree may also cause more serious side effects. These may include depression, prolonged erections, and severe allergic reactions, which might cause rash, hives, or breathing difficulties. If any serious side effects occur, seek medical attention.

References:

  1. Imcivree (Setmelanotide) Product Monograph. Boston, MA: Rhythm Pharmaceuticals; 2023.
  2. Imcivree (Setmelanotide) Drug Label Information. Boston, MA: Rhythm Pharmaceuticals; 2023.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product reviews icon Product Reviews