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| Strength | Pack Size | Qty | |
|---|---|---|---|
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Strength
35mg/100mg
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Inqovi, a combination of cedazuridine and decitabine, belongs to the class of medications known as nucleoside metabolic inhibitors. It mainly treats adult patients with certain myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML). Decitabine interferes with DNA synthesis, while cedazuridine increases decitabine's effectiveness by blocking its breakdown. Administered in tablet form, Inqovi allows for oral treatment that may help some patients manage their conditions without frequent hospital visits for intravenous therapy.
| Fact Table | |
|---|---|
| Formula | Cedazuridine: C9H12FN3O5, Decitabine: C8H12N4O4 |
| License | FDA approved |
| Bioavailability | Increased bioavailability compared to IV decitabine due to cedazuridine |
| Legal status | Prescription only |
| Chemical Name | Cedazuridine: 5-Azacytidine-5'-phosphate deaminase inhibitor, Decitabine: 5-Aza-2'-deoxycytidine |
| Elimination half-life | Cedazuridine: ~1.2 hours, Decitabine: ~0.5 hours |
| Dosage (Strength) | 35 mg Cedazuridine / 100 mg Decitabine tablets |
| Pregnancy | Contraindicated |
| Brands | Inqovi |
| Protein binding | Cedazuridine: Not significant, Decitabine: Less than 1% |
| PubChem CID | Cedazuridine: 5484721, Decitabine: 451668 |
| MedlinePlus | a620011 |
| ChEBI | Cedazuridine: 145780, Decitabine: 25561 |
| ATC code | L01BC08 |
| DrugBank | Cedazuridine: DB12534, Decitabine: DB01262 |
| KEGG | Cedazuridine: D11050, Decitabine: D03696 |
| Routes of administration | By mouth |
Inqovi should be taken orally on an empty stomach, as food can affect the absorption of the medication. The standard dosage involves taking one tablet once a day for the first five days of a 28-day cycle. Each tablet is a fixed-dose combination containing 35 mg of decitabine and 100 mg of cedazuridine. Patients must not eat for at least 2 hours before or 2 hours after taking the tablet.
Consistency in the timing of dosage may support the effectiveness of the drug; thus, patients should take it at the same time each day. In addition, be aware that the therapeutic effects may not be immediate and discontinuing the drug early can limit potential benefits. Always follow the prescribed treatment regimen closely and consult a healthcare provider to monitor for any side effects or necessary changes to the dosage.
The two main active ingredients in Inqovi are decitabine and cedazuridine.
The drug label does not list any specific contraindications. However, avoid taking or using this medication if you have a known hypersensitivity to decitabine or cedazuridine or any component of the formulation.
Inqovi side effects include fatigue, constipation, muscle and joint pain, nausea, and diarrhea. Patients might also experience rashes, dizziness, headaches, coughs, and a decrease in appetite. It's not uncommon for individuals to report respiratory issues, such as shortness of breath and upper respiratory infections, as well as serious conditions like pneumonia.
Serious side effects may include the following:
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