Top brand choice
Strength | Pack Size | Qty | |
---|---|---|---|
Strength
10mg/vial
|
We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Istodax is a prescription medication used for treating certain types of cancer, specifically cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) in adults who have received at least one prior systemic therapy. CTCL is a type of cancer that affects the cells of the immune system.
The active ingredient, romidepsin, is a histone deacetylase inhibitor (HDAC inhibitor) that works by altering gene expression and leading to the death of cancer cells.
Fact Table |
|
Formula |
C24H36N4O6S2 |
License |
US FDA |
Bioavailability |
100% (Intravenous) |
Legal status |
Prescription only |
Chemical Name |
(1R,4E,7S,10S,16E,21R)-7-ethylidene-4,21-bis(1-hydroxyethyl)-14-[(1S)-1-isopropylpropyl]-10,11,20-trimethyl-18,24-dithia-13,17-diazabicyclo[18.3.1]tetracosa-4,16-diene-2,6,12,19-tetrone |
Elimination half-life |
3 hours |
Dosage (Strength) |
10 mg powder for reconstitution for IV infusion |
Pregnancy |
Contraindicated |
Brands |
Istodax |
Protein binding |
92-94% |
PubChem CID |
5352062 |
MedlinePlus |
a611011 |
ChEBI |
CHEBI:367775 |
ATC code |
L01XX42 |
DrugBank |
DB06820 |
KEGG |
D05304 |
Routes of administration |
Intravenous |
Istodax is administered intravenously under the supervision of a healthcare professional. The typical dosage schedule involves infusions given on days 1, 8, and 15 of a 28-day cycle.
This cycle may be repeated based on how well the patient responds to treatment and tolerates the medication.
The active ingredient in Istodax is romidepsin.
Common drug interactions with this medication include:
Before starting Istodax, inform your doctor if you have a history of heart problems, liver issues, or electrolyte imbalances.
Patients should also be aware that Istodax can lower blood cell counts, possibly increasing the risk of infections, bleeding, or anemia.
Women who are pregnant or breastfeeding should not use Istodax, as it may cause harm to the baby. It is important to use effective contraception during treatment.
Istodax binds to estrogen receptors and can reduce the effectiveness of certain types of birth control.
The most common side effects may include:
Istodax [package insert]. Cambridge, MA: Gloucester; 2009.