Istodax (Romidepsin)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
10mg/vial
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Istodax is a prescription medication used for treating certain types of cancer, specifically cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) in adults who have received at least one prior systemic therapy. CTCL is a type of cancer that affects the cells of the immune system.

The active ingredient, romidepsin, is a histone deacetylase inhibitor (HDAC inhibitor) that works by altering gene expression and leading to the death of cancer cells.

Fact Table

Formula

C24H36N4O6S2

License

US FDA

Bioavailability

100% (Intravenous)

Legal status

Prescription only

Chemical Name

(1R,4E,7S,10S,16E,21R)-7-ethylidene-4,21-bis(1-hydroxyethyl)-14-[(1S)-1-isopropylpropyl]-10,11,20-trimethyl-18,24-dithia-13,17-diazabicyclo[18.3.1]tetracosa-4,16-diene-2,6,12,19-tetrone

Elimination half-life

3 hours

Dosage (Strength)

10 mg powder for reconstitution for IV infusion

Pregnancy

Contraindicated

Brands

Istodax

Protein binding

92-94%

PubChem CID

5352062

MedlinePlus

a611011

ChEBI

CHEBI:367775

ATC code

L01XX42

DrugBank

DB06820

KEGG

D05304

Routes of administration

Intravenous

Directions

Istodax is administered intravenously under the supervision of a healthcare professional. The typical dosage schedule involves infusions given on days 1, 8, and 15 of a 28-day cycle.

This cycle may be repeated based on how well the patient responds to treatment and tolerates the medication.

Ingredients

The active ingredient in Istodax is romidepsin.

Interactions

Common drug interactions with this medication include:

  • Apalutamide
  • Atazanavir
  • Boceprevir
  • Carbamazepine
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Enzalutamide
  • Fosphenytoin
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lopinavir
  • Lumacaftor
  • Mitotane
  • Nefazodone
  • Nelfinavir
  • Phenytoin
  • Posaconazole
  • Rifampin
  • Ritonavir
  • Saquinavir
  • St John's Wort
  • Telaprevir
  • Telithromycin
  • Tipranavir
  • Voriconazole

Cautions

Before starting Istodax, inform your doctor if you have a history of heart problems, liver issues, or electrolyte imbalances.

Patients should also be aware that Istodax can lower blood cell counts, possibly increasing the risk of infections, bleeding, or anemia.

Women who are pregnant or breastfeeding should not use Istodax, as it may cause harm to the baby. It is important to use effective contraception during treatment.

Istodax binds to estrogen receptors and can reduce the effectiveness of certain types of birth control.

Side Effects

The most common side effects may include:

  • Anemia
  • Asthenia
  • EKG ST segment changes
  • Epstein-Barr virus disease, Reactivation
  • Fatigue
  • Infectious disease
  • Lymphocytopenia
  • Loss of appetite
  • Nausea
  • Neutropenia
  • Reactivation of hepatitis B viral hepatitis
  • Sepsis
  • Supraventricular arrhythmia
  • Thrombocytopenia
  • Tumor lysis syndrome
  • Ventricular arrhythmia
  • Vomiting

References

Istodax [package insert]. Cambridge, MA: Gloucester; 2009.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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