Kaletra (Ritonavir/Lopinavir)

Prescription medicineOnly Available By Prescription
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Top brand choice

Strength Pack Size Qty
Strength
80mg/20mg
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Strength
200mg/50mg
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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
Strength
80mg/20mg
Pack Size
Qty
Strength
200mg/50mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

If you have human immunodeficiency virus (HIV-1) infection, your doctor may prescribe the medication Kaletra.

Kaletra is often used in combination with other antivirals to stop the replication of HIV and slow down the progression of the disease.

Fact Table

Formula

C37H48N6O5S2

License

EU EMA, US FDA

Bioavailability

-

Legal status

RX Only

Chemical Name

Lopinavir/ritonavir

Elimination half-life

3-5 hours

Dosage (Strength)

80/20mg

Pregnancy

No known risks

Brands

Kaletra, Aluvia

Protein binding

98-99%

PubChem CID

11979606

MedlinePlus

a602015

ChEBI

45409

ATC code

J05AR10

DrugBank

DB00503

KEGG

D02498

Routes of administration

By mouth

Directions

Kaletra comes in the strength 800/200 mg and is given either once or twice daily.

The tablets can be taken with or without food and must be swallowed whole without crushing or chewing them.

Ingredients

The active ingredients in Kaletra are lopinavir and ritonavir.

Interactions

Kaletra contains ritonavir, which causes an intentional drug interaction that increases lopinavir levels in the body. For this reason, there are many drug interactions with Kaletra. Some examples include:

  • Alfuzosin
  • Alprazolam
  • Amiodarone
  • Antihepaciviral combination products
  • Apalutamide
  • Aprepitant
  • Atovaquone
  • Avanafil
  • Bortezomib
  • Bosutinib
  • Budesonide
  • Clarithromycin
  • Clobetasone
  • Cobicistat
  • Darunavir
  • Disulfiram
  • Domperidone
  • Doxorubicin
  • Dronedarone
  • Eletriptan
  • Eplerenone
  • Ergot derivatives
  • Everolimus
  • Flecainide
  • Fluticasone
  • Fosamprenavir
  • Fosaprepitant
  • Ibrutinib
  • Ivabradine
  • Lovastatin
  • Lurasidone
  • Metronidazole
  • Midazolam
  • Pimozide
  • Propafenone
  • Quinidine
  • Quinine
  • Red yeast rice
  • Rifampin
  • Rivaroxaban
  • Salmeterol
  • Simvastatin
  • St. John's Wort
  • Tamsulosin
  • Triazolam
  • Vincristine
  • Voriconazole

Cautions

Tell your doctor if you have a history of kidney or liver problems before starting Kaletra.

Your doctor should screen for heart disease and arrhythmias before you start taking this medication.

Use caution if you have ever had pancreatitis.

Kaletra can affect the levels of blood glucose and cholesterol.

Side Effects

Kaletra side effects may include:

  • Abdominal pain
  • Altered glucose
  • Anemia
  • Anxiety
  • Decreased creatinine clearance
  • Dermatitis
  • Diarrhea
  • Dizziness
  • Erectile dysfunction
  • Hypertension
  • Increased liver enzymes
  • Leukopenia
  • Lower respiratory tract infection
  • Neutropenia
  • Upper respiratory tract infection
  • Vomiting

References

  1. Kaletra [package insert]. Chicago, IL: AbbVie; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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