Korsuva (Difelikefalin)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Korsuva (difelikefalin) is an intravenous (IV) medication administered to adults on hemodialysis (HD) who have moderate to severe itching due to chronic kidney disease.

Fact Table
Formula C36H53N7O6
License FDA approved
Bioavailability Not applicable (intravenous administration)
Legal status Prescription only
Chemical Name Difelikefalin
Elimination half-life Approximately 2-3 hours
Dosage (Strength) 0.5 mg/mL
Pregnancy Consult a healthcare provider
Brands Korsuva
Protein binding 20-24%
PubChem CID 73321969
MedlinePlus Not available
ChEBI Not available
ATC code V03AX30
DrugBank DB12974
KEGG D11626
Routes of administration Intravenous

Directions

Your treatment regimen will be prescribed by your doctor. Korsuva will be given via an IV injection by a healthcare provider after each HD session.

You may refer any questions or concerns to your doctor.

Ingredients

Difelikefalin is the active ingredient in Korsuva.

Contraindications

According to the most recent Prescribing Information, there are no contraindications to Korsuva. Talk to your doctor about whether Korsuva is right for you.

Cautions

  • Before Korsuva treatment is initiated, the following should be discussed with your doctor:
    • All the medications you use, including prescription and nonprescription medications, vitamins, and supplements
    • Your allergies
    • Any existing health concerns
    • Your past medical history
    • If you are pregnant
    • If you are breastfeeding
  • Korsuva contains the following warnings and precautions:
    • Drowsiness, dizziness, mental status changes, and issues with walking
    • Patients should avoid driving, operating machinery, or engaging in other dangerous activities until they know how well they tolerate the medication, as it can cause mental and physical impairments.
  • Korsuva is not recommended for patients with severe liver issues.

Side Effects

Korsuva side effects include but are not limited to nausea, diarrhea, dizziness, drowsiness, issues with walking, falls, elevated blood potassium levels, headache, and mental status changes. Inform your doctor right away of any bothersome or persistent side effects you experience.

Talk to your doctor about Korsuva injection.

Reference

Korsuva. Stamford, CT: Cara Therapeutics, Inc.; 2021.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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