Lioresal (Baclofen)

Description

Lioresal, commonly known by the generic name Baclofen, is a medication used to relieve muscle spasticity. Classified as a muscle relaxer, it works by blocking the transmission of nerve signals that cause muscle rigidity and spasms. Doctors often prescribe Baclofen for managing symptoms associated with conditions like multiple sclerosis and spinal cord injuries, which can include pain, tightness, and clenching of muscles. Though Baclofen does not cure these underlying issues, it may help reduce discomfort and improve mobility for those affected.

Directions

When taking Baclofen, it is important to follow a doctor’s instructions carefully. Patients typically start with a low dose, and doctors may adjust the dosage over time. The initial dosage often begins at 5 mg taken three times a day. While the dosage may be increased, it generally should not exceed 80 mg per day, divided into several doses. It is crucial not to stop taking Baclofen suddenly, as this may lead to withdrawal symptoms. If a doctor decides to discontinue the treatment, they will usually reduce the dose gradually.

Ingredients

The active ingredient in Lioresal is Baclofen.

Contraindications

Avoid taking Lioresal if you have a known hypersensitivity to Baclofen or any component of the formulation.

Cautions

• Before using Lioresal, you may want to consult a healthcare provider about the following:
• Any existing health conditions
• Any allergies
• A list of all medications you are currently taking
• Whether you are pregnant or breastfeeding
• Stopping Lioresal suddenly can cause serious withdrawal symptoms, including hallucinations and seizures. Unless directed by a doctor for a severe reaction, the dosage should be reduced gradually before stopping.
• Since Lioresal is mainly removed from the body through the kidneys, people with kidney disease may need a lower dose. Doctors will monitor kidney function to prevent complications.
• Animal studies suggest that Lioresal may cause birth defects or delayed bone development in unborn babies. There are no well-controlled studies in pregnant women, so it should only be used if absolutely necessary. Pregnant women should discuss risks and benefits with their doctor before taking this medication.
• The safety of Lioresal in children under 12 years old has not been established, so its use in this age group is not recommended.
• Lioresal can cause drowsiness, dizziness, and reduced alertness. Patients should avoid driving, operating heavy machinery, or doing tasks that require full concentration until they know how the medication affects them. Alcohol and other sedating drugs can increase these effects and should be avoided.
• Lioresal may affect seizure control in people with epilepsy. Patients with epilepsy should have regular check-ups, including monitoring of brain activity (EEG), to ensure their condition remains stable.
• It is not known if Lioresal passes into breast milk. As a precaution, breastfeeding while taking this medication is not recommended unless approved by a doctor.
• Some women taking Lioresal long-term have developed ovarian cysts, but these usually go away on their own. The overall risk of ovarian cysts in the general population is between 1% and 5%. If you notice unusual symptoms, talk to your doctor.

Side Effects

The most common side effects of Lioresal include drowsiness, dizziness, weakness, and fatigue. Drowsiness is often temporary and may improve with continued use. Some patients also experience confusion, headache, or insomnia. Gastrointestinal symptoms such as nausea or constipation have been reported but are generally mild.

Lioresal may cause more serious reactions, including low blood pressure, coordination problems, hallucinations, or seizures, though these are rare. Some individuals may also experience urinary issues, such as increased frequency or difficulty urinating. Skin reactions like rash or excessive sweating have been reported in some cases. If you experience chest pain, severe dizziness, or trouble breathing, seek medical attention immediately.

References

1. Lioresal (Baclofen) Product Monograph. Roswell, GA: Saol Therapeutics Inc.; 2019.
2. Baclofen Drug Label Information. Detroit, MI: Caraco Pharmaceutical Laboratories, Ltd.; 2007.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....