Lorbrena (Lorlatinib)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
25mg
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Strength
100mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Lorbrena is an oral tyrosine kinase inhibitor specifically prescribed for the treatment of certain forms of advanced non-small cell lung cancer (NSCLC). It is typically only prescribed by oncologists for the treatment of cancer.

It is a targeted therapy effective against tumors with specific genetic mutations like ALK (anaplastic lymphoma kinase) rearrangements.

Fact Table
Formula C21H19FN6O2
License FDA approved
Bioavailability Approximately 81%
Legal status Prescription only
Chemical Name 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1,4(2H,3H)-dione
Elimination half-life Approximately 24 hours
Dosage (Strength) 25 mg, 100 mg tablets
Pregnancy Not recommended; consult a healthcare provider
Brands Lorbrena
Protein binding Approximately 66%
PubChem CID 71719489
MedlinePlus a618054
ChEBI 134698
ATC code L01XE56
DrugBank DB11749
KEGG D10957
Routes of administration Oral

Directions

The recommended dosage is 100 mg once daily. Do not change or adjust your dosage without speaking with your doctor.

Ingredients

The active ingredient in Lorbrena is loralatinib.

Interactions

Common drug-drug interactions may include:

  • Abametapir
  • Acalabrutinib
  • Alfentanil
  • Amiodarone
  • Aprepitant
  • Atogepant
  • Avacopan
  • Avanafil
  • Avapritinib
  • Boceprevir
  • Bosentan
  • Bosutinib
  • Brigatinib
  • Budesonide
  • Buprenorphine
  • Buspirone
  • Capivasertib
  • Capmatinib
  • Carbamazepine
  • Cenobamate
  • Clarithromycin
  • Cobicistat
  • Cobimetinib
  • Codeine
  • Conivaptan
  • Cyclosporine
  • Daridorexant
  • Darifenacin
  • Darunavir
  • Dasatinib
  • Desogestrel
  • Dienogest
  • Digoxin
  • Dihydroergotamine
  • Dofetilide
  • Dronedarone
  • Drospirenone
  • Duvelisib
  • Efavirenz
  • Elacestrant
  • Eletriptan
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Eplerenone
  • Erdafitinib
  • Ergotamine
  • Estetrol
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etonogestrel
  • Etravirine
  • Everolimus
  • Fedratinib
  • Felodipine
  • Fentanyl
  • Fexinidazole
  • Finerenone
  • Flibanserin
  • Fluconazole
  • Fluticasone
  • Fosaprepitant
  • Fosphenytoin
  • Fruquintinib
  • Gestodene
  • Glasdegib
  • Ibrexafungerp
  • Ibrutinib
  • Idelalisib
  • Ifosfamide
  • Indinavir
  • Infigratinib
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ketoconazole
  • Larotrectinib
  • Lefamulin
  • Lemborexant
  • Lenacapavir
  • Leniolisib
  • Levonorgestrel
  • Lomitapide
  • Lopinavir
  • Lovastatin
  • Lumacaftor
  • Lumateperone
  • Lurasidone
  • Maraviroc
  • Mavacamten
  • Medroxyprogesterone
  • Mestranol
  • Midazolam
  • Mitapivat
  • Mitotane
  • Mobocertinib
  • Modafinil
  • Nafcillin
  • Naloxegol
  • Nefazodone
  • Nelfinavir
  • Neratinib
  • Nirogacestat
  • Nomegestrol
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Olutasidenib
  • Omaveloxolone
  • Oxycodone
  • Pacritinib
  • Palovarotene
  • Pemigatinib
  • Perampanel
  • Phenobarbital
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pirtobrutinib
  • Posaconazole
  • Pralsetinib
  • Pretomanid
  • Primidone
  • Quetiapine
  • Quinidine
  • Quizartinib
  • Repotrectinib
  • Rifabutin
  • Rifampin
  • Rimegepant
  • Ripretinib
  • Ritonavir
  • Saquinavir
  • Segesterone
  • Selpercatinib
  • Selumetinib
  • Sildenafil
  • Simvastatin
  • Sirolimus
  • St John's Wort
  • Tacrolimus
  • Tazemetostat
  • Telaprevir
  • Telithromycin
  • Temsirolimus
  • Ticagrelor
  • Tipranavir
  • Tolvaptan
  • Triazolam
  • Ubrogepant
  • Ulipristal
  • Vardenafil
  • Venetoclax
  • Voclosporin
  • Vonoprazan
  • Voriconazole
  • Voxelotor
  • Zanubrutinib
  • Zolpidem
  • Zuranolone

Cautions

Ask your doctor or pharmacist for a full list of precautions that apply to you.

Side Effects

Common adverse reactions may include:

  • Altered mental status
  • Arthralgia
  • Atrioventricular block
  • Central nervous system finding
  • Diarrhea
  • Dyspnea
  • Dyssomnia
  • Edema
  • Fatigue
  • Hepatotoxicity
  • Hyperglycemia
  • Hyperlipidemia
  • Hypertriglyceridemia
  • Hypertension
  • Impaired cognition
  • Interstitial lung disease
  • Mood swings
  • Peripheral nerve disease
  • Pneumonitis
  • Prolonged PR interval
  • Psychotic disorder
  • Seizure
  • Speech problem
  • Weight gain

References

Lorbrena [package insert]. New York, NY: Pfizer; November 2018.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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