Macrobid (Nitrofurantoin)

Prescription medicineOnly Available By Prescription
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Macrobid is a prescription medication containing nitrofurantoin. It is used for the treatment and prevention of urinary tract infections (UTIs) and other bacterial infections. It belongs to the class of antibiotics known as nitrofurans, which disrupt the synthesis of bacterial cell walls, ultimately leading to bacterial cell death.

Macrobid is specifically effective against bacteria that colonize the urinary tract, making it an effective option for managing UTIs.

The urinary tract is the set of organs that makes and removes urine from the body. During a UTI, bacteria colonize this system, causing symptoms like increased urination, pain, and increased urge to urinate. Women are more likely than men to experience UTIs.

Fact Table
Formula C8H6N4O5
License FDA approved
Bioavailability Approximately 40-50%
Legal status Prescription only
Chemical Name 1-[[(5-Nitro-2-furanyl)methylene]amino]imidazolidine-2,4-dione
Elimination half-life Approximately 20 minutes
Dosage (Strength) 100 mg (capsules)
Pregnancy Category B; consult a healthcare provider, especially near term
Brands Macrobid, Macrodantin
Protein binding Approximately 60%
PubChem CID 6604209
MedlinePlus a682291
ChEBI 63621
ATC code J01XE01
DrugBank DB00698
KEGG D00546
Routes of administration Oral

Directions

The usual dosage is 100 mg by mouth twice daily for one week or at least three days after the urine is sterile.

Macrobid may also be used to prevent UTI by taking it once daily on a long-term basis.

Macrobid is usually taken orally with food to enhance absorption and reduce the risk of stomach upset. It is important to take Macrobid exactly as prescribed by your healthcare provider.

Finish the entire course of antibiotics, even if you start feeling better before the medication is finished.

Ingredients

The active ingredient in Macrobid is nitrofurantoin.

Interactions

Common drug-drug interactions with Macrobid may include:

  • Cholera Vaccine, Live
  • Fluconazole
  • Levoketoconazole
  • Magnesium
  • Methotrexate
  • Probenecid
  • Sulfinpyrazone

Cautions

Patients with a history of renal impairment, liver disease, or glucose-6-phosphate dehydrogenase (G6PD) deficiency should use Macrobid with caution.

It is not recommended for use during the last few weeks of pregnancy due to the risk of hemolytic anemia in newborns.

Side Effects

Common adverse reactions include:

  • Cholestatic jaundice syndrome
  • Erythema multiforme
  • Erythroderma
  • Headache
  • Hepatic necrosis
  • Hepatitis
  • Hepatitis, chronic, Active
  • Hemolytic anemia
  • Hypersensitivity reaction
  • Nausea
  • Pancreatitis
  • Peripheral neuropathy
  • Pulmonary hypersensitivity
  • Stevens-Johnson syndrome

References

Macrobid [package insert]. Morristown, NJ: Almatica Pharma; 2020.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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