Rheumatrex (Methotrexate)

Prescription medicineOnly Available By Prescription
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Rheumatrex, known as Methotrexate, is a medication used to treat some types of cancer, serious skin problems like psoriasis, and certain kinds of arthritis. It helps by slowing down the growth of cancer cells and reducing inflammation in the body. Methotrexate comes in the form of tablets that you take by mouth. Sometimes, healthcare providers may prescribe it along with other medicines for increased effectiveness.

Directions

Rheumatrex is typically taken orally in tablet form, often prescribed at a dosage of 7.5 to 10 milligrams weekly. However, the Rheumatrex dosage depends on the condition being treated. Depending on a person’s needs and doctor's recommendations, the dosage may increase to between 20 and 25 milligrams or more per week. It’s recommended to swallow the tablets whole with a full glass of water rather than breaking, chewing, or crushing them.

Ingredients

The active ingredient in Rheumatrex is Methotrexate.

Contraindications

Avoid taking or using this medication if any of the following apply:

  • Severe hypersensitivity to Methotrexate, including anaphylaxis
  • Pregnancy while being treated for diseases other than cancer

Cautions

  • Before starting treatment with Rheumatrex, make sure to inform your healthcare provider if you have:
    • Any existing health conditions
    • Any allergies
    • A list of all medications you are currently taking
    • Whether you are pregnant or breastfeeding
  • Methotrexate can harm a fetus and should not be used by pregnant women for non-cancer treatments. Pregnant women with cancer should be informed of the risks. Women of childbearing age should use effective birth control during treatment and for six months after the final dose. Men with female partners of childbearing potential should use birth control during treatment and for three months after the last dose.
  • Methotrexate can suppress bone marrow function, leading to serious issues like low blood counts, anemia, or increased infection risk. Regular blood tests are needed to monitor for these effects.
  • Pulmonary toxicity, such as lung inflammation or scarring, can occur and may be irreversible or fatal. Report any breathing problems, cough, or chest pain to your healthcare provider immediately.
  • Severe skin reactions, including life-threatening conditions like Stevens-Johnson syndrome or toxic epidermal necrolysis, may occur. Exposure to sunlight can worsen these reactions. Avoid excessive sun exposure and use sunscreen.
  • Methotrexate can cause kidney damage, including acute kidney failure. Regular monitoring of kidney function is essential. Severe toxicity may require specific treatments, such as glucarpidase.
  • This medication may reactivate sunburn or radiation-related skin damage. Protect your skin from ultraviolet exposure while on treatment.
  • Always follow your healthcare provider's instructions, undergo regular monitoring, and immediately report any unusual or severe symptoms.

Side Effects

Methotrexate commonly causes side effects such as mouth sores, low white blood cell counts, nausea, and upset stomach. These side effects may range from mild to moderate and should be monitored by a healthcare provider. Since Methotrexate affects the immune system, it may increase susceptibility to infections. Any new symptoms, like fever or a general feeling of being unwell, should be reported to your doctor immediately.

Methotrexate can lead to severe and potentially life-threatening side effects, including serious infections like pneumonia, tuberculosis, and hepatitis B reactivation. It may also cause nervous system issues, such as leukoencephalopathy, which can worsen over time and may not be reversible. Secondary cancers, including skin and blood cancers, have been associated with Methotrexate. In addition, Tumor Lysis Syndrome (TLS), a rapid breakdown of cancer cells, can lead to kidney failure and heart rhythm issues. Seek immediate medical attention for symptoms like persistent fever, neurological changes, or signs of severe infection.

References

  1. Methotrexate Product Monograph. Eatontown, NJ: West-Ward Pharmaceuticals Corp.; 2020.
  2. Methotrexate Drug Label Information. Cranbury, NJ: Sun Pharmaceutical Industries, Inc.; 2020.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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