Monoferric (Ferric Derisomaltose)

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Monoferric is an intravenous iron replacement therapy primarily used to treat iron deficiency anemia in adult patients. Administered through infusion, Monoferric replenishes iron levels in individuals with insufficient iron stores, a condition called anemia. Monoferric is typically prescribed for people who have tried and failed oral therapy and who have non-hemodialysis-dependent chronic kidney disease.

A unique feature of Monoferric is its ferric derisomaltose complex, designed for efficient iron delivery while minimizing the risk of hypersensitivity reactions. Different types of iron infusions are available, and your doctor will select the one most appropriate for you. Monoferric is typically used after iron replacement treatments have failed.

Fact Table
Formula Not applicable (complex of iron and carbohydrate)
License FDA approved
Bioavailability Intravenous administration ensures 100% bioavailability
Legal status Prescription only
Chemical Name Ferric derisomaltose (iron-carbohydrate complex)
Elimination half-life The half-life is not well-defined due to complex metabolism and storage of iron
Dosage (Strength) 1000 mg iron per infusion (or other strengths as per clinical requirements)
Pregnancy Consult a healthcare provider; use if clearly needed
Brands Monoferric
Protein binding Iron binds to transferrin in the blood
PubChem CID Not available
MedlinePlus Not available
ChEBI Not available
ATC code B03AC09
DrugBank DB14923
KEGG Not available
Routes of administration Intravenous

Directions

Monoferric is typically through intravenous injection by healthcare professionals in an infusion suite.

The usual dosage for patients 50 kg and over is 1000 mg per infusion. Patients who weigh less than 50 kg will have their dosage determined by their healthcare team.

Ingredients

The active ingredient in monoferric is ferric derisomaltose.

Interactions

Monoferric may interact with the following drugs:

  • Baloxavir Marboxil
  • Bictegravir
  • Carbidopa
  • Cefdinir
  • Ciprofloxacin
  • Delafloxacin
  • Demeclocycline
  • Dimercaprol
  • Dolutegravir
  • Doxycycline
  • Eltrombopag
  • Elvitegravir
  • Ethinyl Estradiol
  • Gatifloxacin
  • Grepafloxacin
  • Levodopa
  • Levofloxacin
  • Levothyroxine
  • Lomefloxacin
  • Magnesium Sulfate
  • Methyldopa
  • Minocycline
  • Moxifloxacin
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Norfloxacin
  • Ofloxacin
  • Omadacycline
  • Omeprazole
  • Penicillamine
  • Raltegravir
  • Temafloxacin
  • Tetracycline
  • Trovafloxacin Mesylate
  • Zinc

Cautions

Patients with a history of allergic reactions to iron products or other components of Monoferric should use caution before starting this drug.

During treatment, monitor for signs of hypersensitivity, such as rash or difficulty breathing.

Additionally, individuals with certain medical conditions, like inflammatory disorders or infections, may require careful assessment before initiating Monoferric therapy.

Side Effects

Common side effects of this infusion may include:

  • Hypersensitivity
  • Hypophosphatemia
  • Iron overload
  • Nausea
  • Rash

References

Monoferric [package insert]. Holbaek, Denmark: Pharmacosmos A/S; January 2010.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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