Only Available By Prescription
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| Strength | Pack Size | Qty | |
|---|---|---|---|
|
Strength
2mg
|
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Myleran (busulfan) is a potent alkylating agent indicated for the palliative treatment of chronic myelogenous leukemia.
Myleran (busulfan) 2 mg oral tablets are what are supplied.
| Fact Table | |
| Formula |
C6H14O6S2 |
| License |
US FDA, EU EMA, US DailyMed |
| Bioavailability |
60–80% |
| Legal status |
Rx-Only |
| Chemical Name |
Busulfan |
| Elimination half-life |
2.5 hours |
| Dosage (Strength) |
2mg |
| Pregnancy |
Contraindicated |
| Brands |
Myleran |
| Protein binding |
32.4% |
| PubChem CID |
2478 |
| MedlinePlus |
a682248 |
| ChEBI |
28901 |
| ATC code |
L01AB01 |
| DrugBank |
DB01008 |
| KEGG |
D00248 |
| Routes of administration |
By mouth |
Myleran dosage for remission induction in adults: 4 mg to 8 mg by mouth by mouth daily
The active ingredient in each Myleran tablet is Busulfan.
Do not take Myleran if you have not been definitively diagnosed with chronic myelogenous leukemia.
If you are allergic to busulfan or any of the other ingredients or excipients in Myleran, do not take the medication. Tell your doctor about any allergies you have.
|
MYLERAN is a potent drug. It should not be used unless a diagnosis of chronic myelogenous leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy. MYLERAN can induce severe bone marrow hypoplasia. Reduce or discontinue the dosage immediately at the first sign of any unusual depression of bone marrow function as reflected by an abnormal decrease in any of the formed elements of the blood. A bone marrow examination should be performed if the bone marrow status is uncertain. SEE WARNINGS FOR INFORMATION REGARDING BUSULFAN-INDUCED LEUKEMOGENESIS IN HUMANS. |
Tell your doctor about all the medications you take, including any that you take over-the-counter. Myerlan can interact with certain medications which can cause unpleasant or serious reactions.
Once you are prescribed and buy Myleran, Myleran may induce bone marrow failure which can cause a decrease in blood cell counts. Extreme caution should be used if your bone marrow reserve has been reduced.
Myleran can cause bronchopulmonary dysplasia with pulmonary fibrosis. Seek medical attention right away if you develop a cough, shortness of breath, and a fever.
Myleran may cause cellular dysplasia in many organs, including the lungs.
Malignant tumors and acute leukemias have been seen in patients who received Myleran.
Premenopausal patients who have received Myleran may experience suppression of the ovaries and absence of menstruation with symptoms of menopause.
Male patients who receive treatment with Myleran may experience sterility, testicular atrophy, and the absence of sperm.
Hepatic veno-occlusive disease can occur with Myleran treatment, especially if taken with cyclophosphamide or other chemotherapy. Liver enzymes should be evaluated.
Some patients with thalassemia who have received Myleran and cyclophosphamide have experienced cardiac tamponade.
Tell your doctor if you are pregnant or plan to become pregnant. Myleran can cause harm to an unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed.
Side effects may occur with the use of Myleran, and some side effects can be severe. Side effects may include:
Tell your doctor right away if you experience side effects that are bothersome or persist.
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