Nardil (Phenelzine)

Description

Nardil (phenelzine sulfate) is a medication prescribed to treat depression in patients clinically characterized as “atypical,” “nonendogenous,” or “neurotic.” Nardil is more appropriate for patients who have failed to adequately respond to other treatments.

Nardil is available in 15 mg film-coated tablets for oral administration.

Directions

Nardil should be taken as prescribed by your doctor, who will determine an appropriate Nardil dosage and treatment regimen for you.

Carefully read the medication guide for further usage instructions.

Store the tablets between 15°C and 30°C (59°F and 86°F).

Any questions or concerns may be referred to your doctor or pharmacist.

Ingredients

Phenelzine sulfate is the active ingredient in Nardil.

Mannitol, USP; croscarmellose sodium, NF; povidone, USP; edetate disodium, USP; magnesium stearate, NF; isopropyl alcohol, USP; purified water, USP; opadry orange Y30-13242A; and simethicone emulsion, USP are the inactive ingredients included.

Contraindications

Do not take Nardil if you are allergic to any of its ingredients or if you have pheochromocytoma, congestive heart failure, severe kidney impairment or kidney disease, a history of liver disease, or liver function tests that are abnormal.

Do not take Nardil with sympathomimetic medications or related compounds, serotonergic medications, meperidine, buspirone HCl, bupropion HCl, guanethidine, dextromethorphan, or central nervous system depressants.

Do not take Nardil with or in rapid succession to other monoamine oxidase inhibitors (MAOIs).

Do not undergo elective surgery necessitating general anesthesia while you are receiving treatment with Nardil. Nardil should be stopped for at least 10 days before undergoing elective surgery.

Cautions

• Before you begin treatment with Nardil, tell your doctor about:
• All the medications you take, including prescription and nonprescription medications
• Your allergies
• Your current health conditions
• Your past medical history
• Your status of pregnancy or breastfeeding
• Nardil is associated with the following Boxed Warning:
• The risk of suicidal behavior and thinking was increased by antidepressants compared to placebo in children, adolescents, and young adults according to short-term studies of major depressive disorder and other psychiatric disorders. This risk must be balanced with the clinical need when anyone is considering the use of Nardil or any other antidepressant in a child, adolescent, or young adult. An increase in the risk of suicidality with antidepressants compared to placebo in adults older than 24 years of age was not shown in the short-term studies, and there was a decrease in risk with antidepressants compared to placebo in adults 65+ years of age.
• Depression and certain other psychiatric disorders are associated with an increased suicide risk. Appropriate and close monitoring for clinical worsening, unusual behavioral changes, and suicidality should occur in patients of all ages who start on antidepressant therapy. Families and caregivers should be instructed to closely monitor and communicate any changes with the prescriber.
• Nardil is not approved for pediatric patients.
• Nardil is associated with the following warnings and precautions:
• Worsening of depression and/or emergence of suicidal behavior and ideation or unusual behavioral changes; all patients taking antidepressants should be closely monitored for clinical worsening, suicidality, and unusual behavioral changes, especially during the first few months of therapy and during dose adjustments. Families and caregivers should be instructed to immediately report unusual behavioral changes, irritability, agitation, and other symptoms to the healthcare provider.
• Hypertensive crises may occur.
• Pickled herring, liver, dry sausage, broad bean pods, sauerkraut, cheese (cottage cheese and cream cheese are okay), yogurt, beer, wine, alcohol-free and reduced-alcohol beer and wine, yeast extract, meat extract, and excessive amounts of caffeine and chocolate should be avoided during treatment with Nardil and for two weeks after stopping the medication. Patients should also avoid any foods rich in protein (i.e., fish, meats, dairy products) that are spoiled or improperly refrigerated, stored, or handled, including foods that possibly underwent protein changes by pickling, fermentation, aging, or smoking.
• Inform your doctor(s) and dentist about all the medications you take, including Nardil.

Side Effects

Nardil side effects may include but are not limited to dizziness, headache, drowsiness, sleep problems, fatigue, weakness, tremors, twitching, myoclonic movements, hyperreflexia, constipation, dry mouth, gastrointestinal problems, increased transaminases, weight gain, low blood pressure, swelling, and sexual disturbances.

Immediately notify your doctor if you experience any bothersome or persistent side effects while taking Nardil.

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Reference

1. Nardil. New York, NY: Parke-Davis Division of Pfizer Inc; 2007.

About Dr. Savannah Muncy (Page Author)

Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....