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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Natazia (estradiol valerate and estradiol valerate/dienogest) is a combined oral contraceptive prescribed for pregnancy prevention and for treating heavy menstrual bleeding.
Natazia comes in a 28-day blister pack that includes the following tablets for oral administration:
| Fact Table | |
|---|---|
| Formula | Estradiol Valerate: C23H32O3 Dienogest: C20H25NO2 |
| License | FDA approved |
| Bioavailability | Estradiol Valerate: Oral bioavailability is variable, but Estradiol has around 5% bioavailability after metabolism. Dienogest: Approximately 91% |
| Legal status | Prescription only |
| Chemical Name | Estradiol Valerate: [(8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] pentanoate Dienogest: (17a)-17-Hydroxy-3-oxo-19-norpregna-4,9-dien-21-nitrile |
| Elimination half-life | Estradiol: Approximately 14 hours Dienogest: Approximately 9-10 hours |
| Dosage (Strength) | Varies: 1 mg Estradiol Valerate, 2 mg Estradiol Valerate / 2 mg Dienogest, 2 mg Estradiol Valerate / 3 mg Dienogest, 1 mg Estradiol Valerate / 3 mg Dienogest (quadriphasic oral contraceptive regimen) |
| Pregnancy | Not recommended; Category X |
| Brands | Natazia (U.S.), Qlaira (International) |
| Protein binding | Estradiol: 98% (bound to sex hormone-binding globulin) Dienogest: 90-95% |
| PubChem CID | Estradiol Valerate: 66461 Dienogest: 68849 |
| MedlinePlus | a601052 (Estradiol), a602008 (Contraceptive) |
| ChEBI | Estradiol Valerate: 490366 Dienogest: 4715 |
| ATC code | G03AB08 |
| DrugBank | Estradiol Valerate: DB13950 Dienogest: DB09124 |
| KEGG | Estradiol Valerate: D00555 Dienogest: D01771 |
| Routes of administration | Oral |
Natazia should be taken as your doctor has instructed. Read the medication guide that comes with your prescription for additional instructions for use.
Recommended dose: Take one tablet by mouth daily at the same time each day. Take the tablets in the order as instructed on the blister pack. Refrain from skipping or delaying your dose by more than 12 hours.
Natazia should be kept out of reach of children and stored at 25°C (77°F).
Do not hesitate to reach out to your doctor or pharmacist with any questions or concerns you have.
Estradiol valerate and estradiol valerate/dienogest are the active ingredients in Natazia.
Natazia should not be given to pregnant patients or patients who are at high risk of arterial or venous thrombotic diseases, have abnormal and undiagnosed uterine bleeding, have breast cancer, or have liver disease or tumors.
Natazia side effects include but are not limited to headache, nausea, breast pain, vomiting, menstrual issues, changes in mood, acne, and weight gain. Call your doctor right away if you experience side effects that are bothersome or persistent.
Searching for a competitive Natazia price? Here, you can buy Natazia.
Natazia. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; 2023.
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