Neptazane (Methazolamide)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Neptazane is a medication prescribed to treat glaucoma, which is characterized by increased pressure within the eye that can lead to vision loss. Glaucoma is a long-term progressive disease that usually affects older adults. Symptoms include eye pain, headaches, rainbow-colored halos, low vision, nausea, and vomiting.

Methazolamide is a carbonic anhydrase inhibitor, which decreases the production of aqueous humor (the fluid in the eye), thereby lowering intraocular pressure. This medication is also occasionally used to treat certain other medical conditions, such as altitude sickness and specific types of seizures.

Fact Table
Formula C5H8N2O3S2
License FDA approved
Bioavailability Approximately 100% (oral administration)
Legal status Prescription only
Chemical Name N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]-acetamide
Elimination half-life Approximately 14 hours
Dosage (Strength) 25 mg, 50 mg tablets
Pregnancy Category C; consult a healthcare provider
Brands Neptazane
Protein binding Approximately 55%
PubChem CID 1679
MedlinePlus a682416
ChEBI 6774
ATC code S01EC03
DrugBank DB00814
KEGG D00649
Routes of administration Oral

Directions

The dosage ranges from 50-100 mg by mouth 2-3 times daily.

Ingredients

The active ingredient in Neptazane is methazolamide.

Interactions

Common drug-drug interactions may include:

  • Aspirin
  • Levoketoconazole
  • Memantine
  • Metformin
  • Methotrexate
  • Topiramate

Cautions

Tell your doctor if you have a history of kidney or liver disease, electrolyte imbalances, or certain blood disorders before starting Neptazane.

This medication can cause significant electrolyte disturbances, so regular blood electrolytes and kidney function monitoring are essential.

Methazolamide can increase the risk of metabolic acidosis, particularly in patients with conditions such as diabetes. Metabolic acidosis is a medical emergency, and symptoms include confusion, fast heartbeat, fatigue, loss of appetite, rapid breathing, nausea, and vomiting.

Severe reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), have been reported. Although rare, fatalities have occurred due to severe reactions; discontinue use if suspected.

Tell your doctor if you have a history of liver problems or hepatic necrosis. Liver side effects have been reported with sulfonamide use. Although rare, fatalities have occurred due to severe reactions; discontinue use if suspected. Hepatic coma may occur in patients with cirrhosis or hepatic insufficiency.

Side Effects

The most common side effects of this drug can include:

  • Agranulocytosis
  • Aplastic anemia
  • Confusion
  • Diarrhea
  • Disorder of taste
  • Electrolyte imbalance
  • Fatigue
  • Fulminant liver failure
  • Hepatic necrosis
  • Loss of appetite
  • Malaise
  • Metabolic acidosis
  • Myopia
  • Nausea
  • Neutropenia
  • Paresthesia
  • Polyuria
  • Pure red cell aplasia
  • Somnolence
  • Stevens-Johnson syndrome
  • Thrombocytopenia
  • Tinnitus
  • Toxic epidermal necrolysis
  • Vomiting

References

Methazolamide [package insert]. Vaughan, Ontario: AA Pharma; July 2010.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product reviews icon Product Reviews