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Nexavar (Sorafenib)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
200mg
Pack Size
Qty
What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Nexavar (sorafenib) is a medication used for treating liver cancer, kidney cancer, and differentiated thyroid cancer that is uncontrolled with radioactive iodine treatment.

Nexavar is supplied in 200 mg tablets for oral administration.

Sorafenib is the generic name of Nexavar.

Fact Table

Formula

C21H16ClF3N4O3

License

US FDA, EMA

Bioavailability

~38–49%

Legal status

Prescription only (Rx)

Chemical Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide

Elimination half-life

~25–48 hours

Dosage (Strength)

200 mg tablets (usual adult dose: 400 mg twice daily)

Pregnancy

Category D – Evidence of fetal risk

Brands

Nexavar

Protein binding

~99.5%

PubChem CID

216239

MedlinePlus

a607052

ChEBI

CHEBI:88255

ATC code

L01XE05

DrugBank

DB00398

KEGG

D06402

Routes of administration

Oral

Directions

Nexavar should be taken as directed by your doctor. Direct any questions or concerns to your doctor or pharmacist.

Your doctor will determine an appropriate treatment regimen for you. The usual dose is to take 400 mg (2 tablets) by mouth twice daily. The medication should not be taken with food.

Ingredients

Sorafenib tosylate is the active ingredient in Nexavar. Croscarmellose sodium, microcrystalline cellulose, hypromellose, sodium lauryl sulphate, magnesium stearate, polyethylene glycol, titanium dioxide and ferric oxide red are the inactive ingredients included.

Contraindications

Nexavar should not be administered to patients with an allergy to any of its ingredients or to patients with squamous cell lung cancer who are taking carboplatin and paclitaxel.

Cautions

  • Before you start begin Nexavar therapy, inform your doctor of:
    • All the medications you take
    • Your allergies
    • Your current health problems
    • Your past medical history
    • Your pregnancy or breastfeeding status
  • Nexavar treatment may be associated with cardiovascular events.
  • Nexavar may increase the risk of bleeding.
  • Nexavar may cause high blood pressure; therefore, blood pressure monitoring should be done every week during the first 6 weeks of treatment then periodically.
  • Nexavar may cause hand-foot skin reactions, rash, and other dermatological reactions that may become life-threatening. Medical care should be requested if you develop signs or symptoms of skin reactions.
  • Nexavar may cause gastrointestinal perforation.
  • Nexavar may cause heart arrhythmias, including QT prolongation.
  • Nexavar may cause liver injury.
  • Nexavar can cause harm to an unborn fetus. Effective contraceptive methods should be used.
  • Nexavar may cause thyroid problems.

Side Effects

Common Nexavar side effects include, but are not limited to, diarrhea, fatigue, infection, hair loss, skin reactions, weight loss, appetite loss, nausea, stomach pains, high blood pressure, and bleeding. Let your doctor know as soon as possible if you experience bothersome or persistent side effects.

You can buy Nexavar right here.

Reference

Nexavar. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; 2018.




IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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April 17, 2025 by Gayle J. (RI, United States)
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