Top brand choice
Strength | Pack Size | Qty | |
---|---|---|---|
Strength
100mg
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Strength
150mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Ofev is a prescription medication given for the treatment of:
It can also be given to slow the rate of pulmonary function decline in those with systemic
sclerosis-associated interstitial lung disease (SSc-ILD).
Ofev is most commonly prescribed by a lung specialist called a pulmonologist.
Ofev is a tyrosine kinase receptor inhibitor. It works by shutting down multiple signal pathways that are associated with lung disease.
Fact Table | |
Formula |
C31H33N5O4 |
License |
US FDA, EU EMA |
Bioavailability |
4.7% |
Legal status |
Rx-only |
Chemical Name |
Nintedanib |
Elimination half-life |
10–15 hrs |
Dosage (Strength) |
100mg, 150mg |
Pregnancy |
Consult Doctor |
Brands |
Vargatef, Ofev |
Protein binding |
97.8% |
PubChem CID |
9809715 |
MedlinePlus |
a615009 |
ChEBI |
85164 |
ATC code |
L01EX09 |
DrugBank |
DB09079 |
KEGG |
D10481 |
Routes of administration |
By mouth |
The usual Ofev dosing is 150 mg by mouth with food twice per day.
The doctor may lower the dose to 100 mg twice daily for people who get side effects while taking Ofev. The lower dosage should also be used for people with liver impairment.
The active ingredient in Ofev is nintedanib.
Ofev has drug-drug interactions with many different medications. Tell your doctor or pharmacist if you are taking:
This is not a complete list of drug-drug interactions with Ofev. Speak with your doctor or pharmacist whenever you started Ofev or a new medication.
Your doctor will test your liver enzymes before starting this medication. Tell your doctor if you have a history of liver disease.
Ofev is toxic to a developing embryo, and the doctor will administer a pregnancy test to females of reproductive age before starting this medication.
Use caution if you have a history of gastrointestinal surgeries or gastrointestinal conditions.
Ofev can increase the risk of thromboembolism (clot) and bleed in certain people.