Oseni (Alogliptin/pioglitazone)

Description

Oseni (alogliptin and pioglitazone) is a drug that is used with diet and exercise to help improve type 2 diabetes in adults.

Directions

Oseni is available as a tablet in various strengths:

12.5 mg alogliptin/15 mg pioglitazone, 12.5 mg/30 mg pioglitazone, 12.5 mg alogliptin/45 mg pioglitazone

25 mg alogliptin/15 mg pioglitazone, 25 mg alogliptin/30 mg pioglitazone, 25 mg alogliptin/45 mg pioglitazone 

Your initial dose will be based on your current treatment and medical condition(s) and should not be more than alogliptin 25 mg/pioglitazone 45 mg per day. 

You may be instructed to take a lower dose if you have heart failure, kidney problems, or if you take certain medications such as gemfibrozil.

Oseni may be taken with or without food. 

Ingredients

Alogliptin and pioglitazone are the active ingredients contained in Oseni.

Contraindications

Talk to your doctor about your allergies. You should not take Oseni if you are allergic to alogliptin, pioglitazone, or any of the other ingredients in Oseni.

You should not take Oseni if you have been diagnosed with NYHA Class III or IV heart failure.

Cautions

• Before you start Oseni, tell your doctor:
• About any medications you take, including prescription, non-prescription, vitamins, and herbal supplements
• About any of your medical conditions
• If you are pregnant or plan to become pregnant
• If you are breastfeeding or plan to breastfeed
• Congestive heart failure may worsen or occur with the use of Oseni. Contact your doctor right away if you experience trouble breathing with activity or when lying down, fatigue, weakness, swelling in the abdomen, legs, ankles, and feet, abnormal heart beat, a cough that won't go away, rapid weight gain, nausea, no appetite, problems concentrating, or chest pain. 
• Acute pancreatitis can occur with the use of Oseni. Seek care right away if you experience abdominal pain, pain that radiates from your abdomen to your back, tenderness of the abdomen, fever, fast pulse, nausea, and vomiting.
• Liver problems can occur with the use of Oseni and can be fatal. 
• Swelling can occur with the use of Oseni.
• Fractures can occur in female patients who take Oseni.
• Bladder cancer can occur with the use of Oseni. Caution should be used if you have ever had bladder cancer. You should not take Oseni if you have active bladder cancer. 
• You may experience low blood sugar if you take Oseni with insulin or other medications that can also lower your blood sugar. Watch for signs of low blood sugar. Treat your low blood sugar as your doctor has instructed.
• Tell your doctor if you develop vision changes. 

Side Effects

Common cold, back pain, and upper respiratory tract infection are the most common side effects of Oseni. Tell your doctor right away if you develop side effects that are bothersome or won't go away.

References:

1. Oseni Prescribing Information. Deerfield, IL: Takeda Pharmaceuticals America Inc.; 2013.
2. Heart failure. Mayo Clinic. December 10, 2021. Accessed February 4, 2022.
3. Pancreatitis. Mayo Clinic. September 24, 2021. Accessed February 4, 2022.

About Dr. Savannah Muncy (Page Author)

Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....