Oxlumo (Lumasiran)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
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  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Oxlumo (Lumasiran) is a medication used to treat primary hyperoxaluria type 1 (PH1), a rare genetic disorder. It works by targeting and suppressing the HAO1 gene, which reduces the activity of glycolate oxidase enzymes responsible for the excessive production of oxalate. By doing so, Oxlumo helps decrease oxalate levels in the urine and blood, which are typically elevated in individuals with PH1. Lumasiran is administered as a subcutaneous injection, meaning it is delivered under the skin, providing a viable treatment option for managing the condition and its related symptoms.

Directions

Oxlumo is designed for subcutaneous administration, which means patients should inject it under the skin. The exact dosage may vary based on body weight. For people who weigh 20 kg or 44 pounds or more, Oxlumo dosing typically starts with three loading doses of 3 mg/kg administered at monthly intervals, followed by maintenance doses of 3 mg/kg every three months.

Patients or caregivers should receive proper training to ensure they administer Oxlumo correctly, and they should always inspect the solution before use, ensuring it is clear and colorless to pale yellow without particles. It’s important to rotate injection sites to reduce the risk of site reactions, selecting a different area on the abdomen, thigh, or upper arm for each injection.

Ingredients

The main active ingredient in Oxlumo is Lumasiran Sodium.

Contraindications

There are no listed contraindications on the drug label. However, those with a known hypersensitivity to Lumasiran or any component of the formulation should avoid this medication.

Cautions

  • Before beginning treatment with Oxlumo, it's important to discuss the following with your healthcare provider:
    • Your current health conditions
    • Any allergies you may have
    • All medications you are currently using
    • Whether you are pregnant or breastfeeding
  • Oxlumo is clear, colorless-to-yellow, and ready-to-use without needing reconstitution. Do not use it if the solution is cloudy, discolored, or contains particles.
  • Administer Oxlumo using aseptic technique to prevent contamination.
  • The effects of Oxlumo during pregnancy are unknown as there is no data available on pregnant women. Animal studies showed no adverse effects at doses far exceeding the human dose.
  • It is not known whether Oxlumo is present in human milk or if it affects milk production. The benefits of breastfeeding should be weighed against the potential risks of the drug.
  • Oxlumo is safe and effective for use in newborns and older pediatric patients. Clinical studies support its use in various age groups, including those with chronic kidney disease.

Side Effects

The most common side effects experienced by patients using Oxlumo are related to the injection site. These reactions include redness, swelling, pain, bruising, itching, and discoloration. These symptoms are usually mild and resolve within a day without requiring discontinuation of treatment. Other less common side effects reported include various types of stomach pain.

References:

  1. Oxlumo (Lumasiran) Product Monograph. Cambridge, MA: Alnylam Pharmaceuticals, Inc.; 2023.
  2. Oxlumo (Lumasiran) Drug Label Information. Cambridge, MA: Alnylam Pharmaceuticals, Inc.; 2023.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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