Pravachol (Pravastatin)

Description

Pravachol (Pravastatin) belongs to a group of medications called statins that are used to lower cholesterol. Statins work by blocking a substance your body needs to make cholesterol, which may help to prevent heart disease and stroke. Doctors often prescribe Pravachol to help control high cholesterol and triglyceride levels in the blood. It's also used to prevent heart complications like angina, heart attacks, and strokes, particularly in people who already have heart disease or are at high risk.

Directions

Pravachol is typically taken orally once daily, with or without food. It's important to follow a doctor's instructions closely regarding the right Pravachol dosage, which may vary based on individual health needs. The standard dosage often starts at 40 mg or 80 mg once daily for adults, but a doctor may adjust this over time. The dosage is typically lower for children and people with severe kidney problems. Always take Pravachol at the same time each day to maintain an even level in your bloodstream. Swallow the tablet whole, with a full glass of water. Do not break, crush, or chew the tablets.

Ingredients

The active ingredient in Pravachol is Pravastatin.

Contraindications

Avoid taking Pravachol if any of the following apply:

• Known hypersensitivity or allergic reactions to Pravastatin or any ingredient in the formulation
• Active liver disease, which includes chronic alcoholic liver disease, hepatitis, or other persisting liver conditions

Cautions

• Before using Pravachol, you may want to consult a healthcare provider about the following:
• Any existing health conditions
• Any allergies
• A list of all medications you are currently taking
• Whether you are pregnant or breastfeeding
• Pravachol can cause muscle pain, weakness, or damage (myopathy), which in rare cases can lead to a serious condition called rhabdomyolysis. This can cause kidney damage and, in extreme cases, kidney failure. The risk is higher for older adults, those with kidney problems or uncontrolled thyroid disease, and people taking certain other medications.
• In rare cases, Pravachol has been linked to an immune-related muscle condition called immune-mediated necrotizing myopathy (IMNM). This condition causes ongoing muscle weakness and high levels of muscle enzymes in the blood, even after stopping the medication. It may require treatment with immune-suppressing medications.
• Pravachol may cause liver enzyme levels to rise, though this often happens early in treatment and resolves on its own. However, serious liver damage, including liver failure, has been reported. People who drink large amounts of alcohol or have a history of liver disease may be at higher risk.
• Pravachol, like other statins, may slightly raise blood sugar levels, potentially increasing the risk of diabetes. Maintaining a healthy diet, exercising regularly, and managing weight can help reduce this risk. If you have concerns about your blood sugar levels, discuss them with your doctor.

Side Effects

The most common side effects of Pravachol include muscle pain, upper respiratory infections, and dizziness. Some patients may also experience nausea, diarrhea, fatigue, or headaches. Rash, sinus abnormalities, and chest pain have also been reported. These side effects are usually mild and may improve over time.

Pravachol may cause serious muscle-related issues, including myopathy and rhabdomyolysis, which can lead to kidney problems. Liver problems, including hepatitis and liver failure, have been reported in rare cases. Some patients have experienced cognitive effects such as memory loss, confusion, or forgetfulness, which were usually reversible after stopping the medication. If you develop unexplained muscle pain, weakness, jaundice, or significant changes in mental function, contact a healthcare provider immediately.

References

1. Pravachol (Pravastatin) Product Monograph. Princeton, NJ: Bristol-Myers Squibb Company; 2022.
2. Pravachol (Pravastatin) Drug Label Information. Covington, KY: NCS HealthCare of KY, LLC dba Vangard Labs; 2024.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....