Prempro (Estrogen/Medroxyprogesterone)

Also Known as Premia Continuous, Premique

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
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0.30mg/1.5mg
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Strength
0.45mg/1.5mg
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Strength
0.625mg/2.5mg
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Strength
0.625mg/5.0mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Prempro is a combination hormone replacement therapy (HRT) medication consisting of conjugated estrogens and medroxyprogesterone acetate.

Your doctor may prescribe Prempro to relieve symptoms of menopause, such as night sweats, hot flashes, and vaginal dryness. Prempro works by replenishing the levels of estrogen and progesterone hormones in the body, which decline during menopause, helping to alleviate symptoms and improve quality of life.

Fact Table

Formula

C24H34O4

License

FDA approved

Bioavailability

Estrogens: Variable; Medroxyprogesterone: Well absorbed

Legal status

Prescription only

Chemical Name

Estrogen/Medroxyprogesterone

Elimination half-life

Estrogens: Variable; Medroxyprogesterone: Approximately 24-34 hours

Dosage (Strength)

Available in several strengths; common: 0.3 mg conjugated estrogens/1.5 mg medroxyprogesterone acetate

Pregnancy advice

Contraindicated

Brands

Prempro

Protein binding

Estrogens: Highly bound to serum proteins; Medroxyprogesterone: 90-95% bound

PubChem CID

6289

MedlinePlus

a601050

ChEBI

Medroxyprogesterone:6727

ATC code

G03FA (Combinations of estrogens and progestogens)

DrugBank

DB00603

KEGG

D00951

Routes of administration

Oral

Directions

Take Prempro as prescribed by your doctor. Do not change the dosage without consulting your healthcare provider.

Ingredients

The active ingredients in Prempro are estrogen and medroxyprogesterone.

Interactions

Common drug-drug interactions may include:

  • Amifampridine
  • Apalutamide
  • Aprepitant
  • Armodafinil
  • Artemether
  • Belzutifan
  • Bexarotene
  • Bosentan
  • Bupropion
  • Carbamazepine
  • Cenobamate
  • Clobazam
  • Dabrafenib
  • Darunavir
  • Dexamethasone
  • Donepezil
  • Efavirenz
  • Elagolix
  • Elvitegravir
  • Enasidenib
  • Encorafenib
  • Enzalutamide
  • Eslicarbazepine Acetate
  • Etravirine
  • Fosaprepitant
  • Fosphenytoin
  • Griseofulvin
  • Isotretinoin
  • Ivosidenib
  • Lesinurad
  • Lorlatinib
  • Lumacaftor
  • Mavacamten
  • Meropenem
  • Mitapivat
  • Mitotane
  • Mobocertinib
  • Modafinil
  • Mycophenolic Acid
  • Nafcillin
  • Nevirapine
  • Oxcarbazepine
  • Phenobarbital
  • Phenylbutazone
  • Phenytoin
  • Pitolisant
  • Prednisone
  • Primidone
  • Red Clover
  • Repotrectinib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Rufinamide
  • Secobarbital
  • St John's Wort
  • Sugammadex
  • Tazemetostat
  • Telaprevir
  • Theophylline
  • Topiramate
  • Ulipristal
  • Amifampridine
  • Apalutamide
  • Aprepitant
  • Armodafinil
  • Artemether
  • Belzutifan
  • Bexarotene
  • Bosentan
  • Bupropion
  • Carbamazepine
  • Cenobamate
  • Clobazam
  • Dabrafenib
  • Darunavir
  • Dexamethasone
  • Donepezil
  • Efavirenz
  • Elagolix
  • Elvitegravir
  • Enasidenib
  • Encorafenib
  • Enzalutamide
  • Eslicarbazepine Acetate
  • Etravirine
  • Fosaprepitant
  • Fosphenytoin
  • Griseofulvin
  • Isotretinoin
  • Ivosidenib
  • Lesinurad
  • Lorlatinib
  • Lumacaftor
  • Mavacamten
  • Meropenem
  • Mitapivat
  • Mitotane
  • Mobocertinib
  • Modafinil
  • Mycophenolic Acid
  • Nafcillin
  • Nevirapine
  • Oxcarbazepine
  • Phenobarbital
  • Phenylbutazone
  • Phenytoin
  • Pitolisant
  • Prednisone
  • Primidone
  • Red Clover
  • Repotrectinib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Rufinamide
  • Secobarbital
  • St John's Wort
  • Sugammadex
  • Tazemetostat
  • Telaprevir
  • Theophylline
  • Topiramate
  • Tranexamic Acid
  • Ulipristal

Cautions

Prempro should be used with caution in patients with a history of breast or endometrial cancer or cardiovascular disease.

Long-term use of Prempro may increase the risk of certain health conditions, like breast cancer, stroke, and clots.

Your doctor should regularly monitor the response to treatment during Prempro.

Side Effects

Tell your doctor and pharmacist about any of the following drugs you are taking:

  • Abdominal pain
  • Breast cancer
  • Cerebrovascular accident
  • Depression
  • Disorder of gallbladder
  • Dysmenorrhea
  • Endometrial carcinoma
  • Headache
  • Hypertension
  • Myocardial infarction
  • Nausea
  • Ovarian cancer
  • Pain of breast
  • Pharyngitis
  • Pulmonary embolism
  • Thrombosis of retinal vein
  • Venous thrombosis

References

Prempro [package insert]. Philadelphia, PA: Wyeth; 2009.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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