Procardia (Nifedipine)

Prescription medicineOnly Available By Prescription

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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Procardia is a prescription medication primarily used to treat hypertension and angina. High blood pressure is one of the leading causes of cardiac death worldwide, but it often goes undiagnosed because it doesn’t show symptoms. Angina is easier for a person to detect because the symptoms are chest pain.

Nifedipine is a calcium channel blocker. It relaxes and widens blood vessels, allowing blood to flow more easily, which helps lower blood pressure and reduce chest pain.

Procardia is also sometimes used for Raynaud's phenomenon, which causes the extremities, such as fingers and toes, to feel abnormally numb and cold during cold temperatures.

Fact Table
Formula C17H18N2O6
License FDA approved
Bioavailability Approximately 45-75% (due to first-pass metabolism)
Legal status Prescription only
Chemical Name 3,5-Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Elimination half-life Approximately 2-5 hours (immediate-release)
Dosage (Strength) 10 mg, 20 mg, 30 mg, 60 mg, 90 mg capsules and extended-release tablets
Pregnancy Category C; consult a healthcare provider
Brands Procardia, Adalat, Nifedical, Afeditab
Protein binding Approximately 92-98%
PubChem CID 4485
MedlinePlus a684028
ChEBI 7565
ATC code C08CA05
DrugBank DB01115
KEGG D00442
Routes of administration Oral

Directions

The directions depend on the condition being treated. The usual starting dose for blood pressure control is 30-60 mg orally once daily, and the maximum daily dosage is 120 mg.

Ingredients

The active ingredient in Procardia is nifedipine.

Interactions

Tell your doctor and pharmacist if you take any of the following:

  • Abametapir
  • Amobarbital
  • Aprobarbital
  • Armodafinil
  • Atazanavir
  • Boceprevir
  • Bosentan
  • Butabarbital
  • Butalbital
  • Carbamazepine
  • Ceritinib
  • Clarithromycin
  • Clobazam
  • Clopidogrel
  • Cobicistat
  • Conivaptan
  • Cyclosporine
  • Dantrolene
  • Darunavir
  • Dexamethasone
  • Digoxin
  • Efavirenz
  • Enzalutamide
  • Epirubicin
  • Erythromycin
  • Etravirine
  • Fedratinib
  • Fentanyl
  • Fexinidazole
  • Fluconazole
  • Fluoxetine
  • Fosnetupitant
  • Fosphenytoin
  • Idelalisib
  • Itraconazole
  • Ketoconazole
  • Lacosamide
  • Lonafarnib
  • Mavacamten
  • Melphalan
  • Mephobarbital
  • Methohexital
  • Mibefradil
  • Micafungin
  • Mifepristone
  • Modafinil
  • Nafcillin
  • Nefazodone
  • Nelfinavir
  • Netupitant
  • Nevirapine
  • Omaveloxolone
  • Oxcarbazepine
  • Pentobarbital
  • Phenobarbital
  • Phenytoin
  • Pioglitazone
  • Posaconazole
  • Prednisone
  • Primidone
  • Quinidine
  • Repotrectinib
  • Ribociclib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Rufinamide
  • Saquinavir
  • Secobarbital
  • St John's Wort
  • Tacrolimus
  • Telaprevir
  • Telithromycin
  • Thiopental
  • Topiramate
  • Troleandomycin
  • Tucatinib
  • Voriconazole

Cautions

Tell your doctor if you have a history of heart conditions, liver disease, or kidney disease before starting Procardia.

Procardia can cause a significant drop in blood pressure when starting the medication or adjusting the dose. Regular blood pressure and heart rate monitoring are essential while taking this drug.

Side Effects

Common adverse reactions include:

  • Aplastic anemia
  • Cough
  • Dyspnea
  • Dizziness
  • Feeling nervous
  • Flushing
  • Gastrointestinal obstruction
  • Gastrointestinal ulcer
  • Headache
  • Hypotension
  • Myocardial infarction
  • Nausea
  • Palpitations
  • Peripheral edema
  • Ventricular arrhythmia

References

Procardia [package insert]. New York, NY: Pfizer; July 2013.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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