Promacta (Eltrombopag)

Description

Promacta is an oral medication prescribed to treat the following conditions:

• Thrombocytopenia in adult and pediatric patients at least one year of age or older and have not efficiently responded to corticosteroids, immunoglobulins, or splenectomy
• Thrombocytopenia in patients who suffer from chronic hepatitis C
• In combination with other therapies for severe aplastic anemia in adult and pediatric patients at least 2 years old or older
• Aplastic anemia in patients who have not efficiently responded to immunosuppressive therapy

Promacta is available in 12.5 mg, 25 mg, 50 mg, and 75 mg tablets to be taken by mouth.

Promacta is also available in a 12.5 mg or 25 mg oral suspension.

Directions

Promacta should be taken as your doctor has prescribed. If you have any questions or concerns, speak with your doctor or pharmacist.

Depending on your age and the condition being treated, information concerning your dosage and treatment regimen will be provided to you by your doctor. You should wait to take Promacta at least 2 hours before or 4 hours after antacids, calcium-rich foods, and mineral supplements.

Promacta tablets and oral suspension should be stored at room temperature between 68°F and 77°F (20°C and 25°C). After mixing the oral suspension, administer it immediately. Any remainder should be properly discarded after 30 minutes.

Keep all medications away from children.

Ingredients

The active ingredient in Promacta is eltrombopag olamine. Inactive ingredients contained in the tablets include the following: magnesium stearate, mannitol, microcrystalline cellulose, povidone, sodium starch glycolate, FD&C Blue No. 2 aluminum lake (50-mg tablet), FD&C Yellow No. 6 aluminum lake (25-mg tablet), hypromellose, Iron Oxide Black and Iron Oxide Red (75-mg tablet), polyethylene glycol 400, polysorbate 80 (12.5-mg tablet), or titanium dioxide.

Mannitol, sucralose, and xanthan gum are the inactive ingredients in the oral suspension.

Contraindications

According to Promacta’s most recent Prescribing Information, there are no known contraindications.

Cautions

Promacta contains the following FDA Boxed Warning:

• Patients who take Promacta with interferon and ribavirin may be at increased risk of liver problems.
• Severe and potentially life-threatening liver toxicity may be increased by Promacta. Liver function should be monitored and dosing discontinued as recommended.

• Before you begin treatment with Promacta, tell your doctor:
• About all prescription and nonprescription medications you take
• If you have any allergies
• Your medical history
• Your current health conditions
• If you are pregnant or breastfeeding
• Promacta can cause liver problems. Monitoring of liver function should take place before and during treatment.
• While taking Promacta, there is an increased risk of death and progression of myelodysplastic syndromes to acute myeloid leukemia.
• Promacta can cause a blockage or narrowing of the blood vessel that brings blood to the liver by a blood clot. Regular monitoring of platelets should be performed.
• It is not recommended that women breastfeed during Promacta treatment.

Side Effects

Some, but not all, Promacta side effects include anemia, nausea, fever, increased liver enzymes, cough, fatigue, headache, and diarrhea. If you develop troublesome or persistent side effects, immediately talk to your doctor.

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Reference

Promacta. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2023.

About Dr. Savannah Muncy (Page Author)

Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....