Rifadin (Rifampicin)

Description

Rifadin, or Rifampicin, is a type of antibiotic that is important for treating tuberculosis (TB), a serious lung infection. It works by targeting and stopping the bacteria that cause TB from growing and spreading in the body. Rifadin belongs to a group of antibiotics called rifamycins, which are effective against bacteria in different parts of the body. Usually, Rifadin is used along with other medicines to fight TB more effectively.

Directions

Rifadin should be taken as directed by a healthcare provider. It is typically taken orally on an empty stomach, either 1 hour before a meal or 2 hours after eating. The standard dosage often depends on body weight and the condition being treated. For example, adults being treated for tuberculosis may consume dosages that relate to their body weight, which must be accurately determined by a healthcare professional. Dosage adjustments should not be made without consulting a doctor.

Ingredients

The active ingredient in Rifadin is Rifampicin.

Contraindications

Avoid taking or using this medication if any of the following apply:

• Known allergy to Rifampicin or any of the ingredients in the formulation
• Use with certain medications that may interact negatively, such as protease inhibitors or certain antiretrovirals used in HIV therapy.

Cautions

• Before taking Rifadin, you may want to consult a healthcare provider about the following:
• Any existing health conditions
• Any allergies
• A list of all medications you are currently taking
• Whether you are pregnant or breastfeeding

• Rifadin can affect your liver, potentially causing mild enzyme changes, jaundice, hepatitis, and in rare cases, liver failure or death. People with liver problems or those taking other medications that also affect the liver are at higher risk. Your doctor may order regular blood tests to check your liver during treatment.
• Rifadin may cause serious allergic reactions, including rash, fever, swelling, chest tightness, or breathing trouble. If you notice any of these symptoms, stop taking Rifadin and get medical help immediately. Some people may experience flu-like symptoms (like chills, weakness, or body aches) even without a rash.
• Rare but dangerous skin reactions such as Stevens-Johnson Syndrome (SJS) or toxic epidermal necrolysis (TEN) have been reported. These may begin with a painful rash, blisters, or peeling skin. If any skin reaction happens, stop the medication and contact your doctor immediately.
• Rifadin can lower vitamin K levels and lead to bleeding problems, especially if you have poor nutrition, liver disease, or are on blood thinners. You may need blood tests during treatment. Signs of bleeding include bruising easily, nosebleeds, or unusual bleeding—contact your doctor if these occur.
• Rifadin has been linked to serious lung side effects, including pneumonia, lung inflammation, and even respiratory failure. Let your doctor know if you develop a new cough, chest pain, or shortness of breath.
• Rifadin interacts with many other medications, including birth control pills, blood thinners, seizure medications, HIV drugs, and antidepressants. It can either make other drugs less effective or increase the risk of side effects. Always tell your doctor and pharmacist about all medications and supplements you take.
• Because Rifadin can lower the effectiveness of hormonal birth control (like the pill or patch), use a non-hormonal method, like condoms, while on this medication.
• Rifadin should only be used during pregnancy if clearly needed. It may harm the fetus, especially if taken in the later stages of pregnancy. It can also pass into breast milk, so talk to your doctor about whether to breastfeed while on Rifadin.
• Rifadin can turn your urine, sweat, saliva, tears, and even contact lenses a reddish-orange color. This is harmless but may be surprising if you're not expecting it.
• For best results, take Rifadin exactly as prescribed. Don’t skip doses or stop early, even if you feel better, as this can lead to antibiotic resistance and treatment failure.

Side Effects

The most common side effects of Rifadin include gastrointestinal problems such as nausea, vomiting, abdominal discomfort, diarrhea, and flatulence. Some people may also experience headache, dizziness, fatigue, or skin reactions like rash and itching. Liver-related side effects, including elevated liver enzymes and hepatitis, can occur and may require monitoring. Tooth discoloration and menstrual changes have also been reported.

More serious but less common effects include blood disorders like thrombocytopenia, leukopenia, and hemolytic anemia, especially with intermittent or improperly resumed dosing. Rare cases of renal failure, psychosis, visual disturbances, and severe skin reactions such as Stevens-Johnson syndrome have occurred. Hypersensitivity reactions, including anaphylaxis and pulmonary complications like interstitial lung disease or respiratory distress, have been noted. If symptoms such as rash, fever, confusion, or trouble breathing develop, immediate medical attention is recommended.

References

1. Rifadin (Rifampicin) Product Monograph. Bridgewater, NJ: Sanofi-Aventis U.S. LLC; 2024.
2. Rifadin (Rifampicin) Drug Label Information. Bridgewater, NJ: Sanofi-Aventis U.S. LLC; 2024.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....