Rozlytrek (Entrectinib)

Prescription medicineOnly Available By Prescription
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200mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Rozlytrek (Entrectinib) is a medicine used to treat certain types of cancer. It specifically targets changes in genes, like ROS1 and NTRK, that can help cancer grow. This drug is useful for people with ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. Rozlytrek works by stopping proteins that help cancer cells grow, which can help slow down the growth of tumors.

Directions

Rozlytrek should be taken orally, with or without food. Individuals may mix the oral pellets with soft foods like applesauce or yogurt to make swallowing easier. It's important to follow the prescribed instructions closely. For adults with ROS1-positive non-small cell lung cancer, healthcare providers usually prescribe Rozlytrek at a dose of 600 mg once daily. For children, the dosage is adjusted based on body surface area, considering factors like age and weight.

Ingredients

Rozlytrek contains the active ingredient Entrectinib.

Contraindications

The drug label does not specify any particular contraindications. However, people should avoid taking Rozlytrek if they are allergic to Entrectinib or any other ingredients in the medication.

Cautions

  • Before using Rozlytrek, ensure you provide your healthcare provider with the following information:
    • Existing health conditions
    • Known allergies
    • A list of all the medications you are currently taking
    • Your pregnancy or breastfeeding status
  • Do not use Rozlytrek if you have a serious or active heart condition. If you have a history of heart problems, watch for signs like shortness of breath or swelling and contact your doctor immediately.
  • Rozlytrek can affect your thinking and mood. You might experience confusion, memory issues, anxiety, or depression. If you notice any changes, talk to your healthcare provider right away.
  • Taking Rozlytrek may increase your risk of bone fractures, especially in children. Be careful to avoid falls and inform your doctor if you experience any bone pain or fractures.
  • Rozlytrek can impact your liver health. Your doctor will monitor your liver enzymes during treatment. If you feel unusually tired, nauseous, or notice yellowing of your skin or eyes, contact your doctor immediately.
  • Rozlytrek may raise your uric acid levels, which can lead to gout. Watch for symptoms like sudden joint pain and let your doctor know if they occur.
  • Rozlytrek can affect your heart's rhythm. If you have a history of heart rhythm issues or are taking other heart medications, discuss this with your doctor before starting Rozlytrek.
  • Rozlytrek might cause changes in your vision, such as blurred vision or sensitivity to light. If you experience any vision changes, stop taking Rozlytrek and seek medical advice immediately.
  • Rozlytrek can harm an unborn baby. If you are pregnant or planning to become pregnant, use effective contraception during treatment and for five weeks after the last dose. Men with female partners who can become pregnant should use contraception during treatment and for three months after the last dose.

Side Effects

Common side effects of Rozlytrek include tiredness, nausea, and weight gain. You might also experience constipation, muscle pain, joint pain, and dizziness. Some people report changes in taste, vision problems, or mental status changes like confusion and memory issues. Other side effects can include swelling and fever.

Rozlytrek can cause serious side effects, including congestive heart failure, which may result in symptoms like shortness of breath, swelling in your legs, and fatigue. It can also affect the nervous system, causing confusion, dizziness, or hallucinations. Bone fractures, liver issues, and increased uric acid levels are also possible. If you experience chest pain, vision changes, or any unusual symptoms, contact your healthcare provider right away.

References

  1. Rozlytrek (Entrectinib) Product Monograph. South San Francisco, CA: Genentech USA, Inc.; 2024.
  2. Rozlytrek (Entrectinib) Drug Label Information. South San Francisco, CA: Genentech USA, Inc.; 2024.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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