Ruxience (Rituximab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Ruxience (rituximab-pvvr) injection is used for treating adults who have non-Hodgkin's Lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, or granulomatosis with polyangiitis and microscopic polyangiitis.

Fact Table
Formula C6416H9874N1688O1987S44
License FDA approved
Bioavailability Not applicable (intravenous administration)
Legal status Prescription only
Chemical Name Rituximab
Elimination half-life Approximately 18 days
Dosage (Strength) 100 mg/10 mL, 500 mg/50 mL
Pregnancy Consult a healthcare provider
Brands Ruxience, Rituxan, MabThera
Protein binding Not significantly bound to plasma proteins
PubChem CID 5283560
MedlinePlus a607038
ChEBI 73252
ATC code L01XC02
DrugBank DB00073
KEGG D02995
Routes of administration Intravenous

Directions

A treatment plan will be decided by your healthcare provider. A healthcare professional will administer Ruxience intravenous (IV) infusion. Any questions or concerns may be referred to your healthcare provider.

Ingredients

Rituximab-pvvr is the active ingredient in Ruxience.

Edetate disodium dihydrate, L-histidine, L-histidine hydrochloride monohydrate, polysorbate 80, sucrose, and Water for Injection are the inactive ingredients.

Contraindications

According to the most recent Prescribing Information, there are no contraindications to Ruxience.

Cautions

  • Ruxience is associated with the following FDA Boxed Warning:
    • Potentially fatal infusion-related reactions may occur within 24 hours of receiving the infusion; about 80% of reactions that resulted in death occurred with the first infusion. Patients should receive monitoring; Ruxience should be discontinued if a patient develops severe reactions.
    • Potentially fatal severe mucocutaneous reactions can occur.
    • Hepatitis B reactivation that may lead to fulminant liver inflammation, liver failure, and death may occur.
    • Potentially fatal progressive multifocal leukoencephalopathy (PML) may occur.
  • Before you start receiving Ruxience, discuss the following with your healthcare provider:
    • All the prescription and nonprescription medications you take, including vitamins, herbals, and supplements
    • Your allergies
    • Your current health problems
    • Your past medical history
    • If you are pregnant or breastfeeding
  • The following may occur with Ruxience treatment:
    • Tumor lysis syndrome
    • Infections
    • Cardiac adverse reactions
    • Kidney issues
    • Bowel obstruction and perforation
    • Fetal harm; therefore, females of childbearing potential are advised to use effective contraceptive methods during Ruxience treatment and for 12 months after receiving the final dose.
  • Breastfeeding is not advised.
  • Patients on Ruxience treatment should not receive live vaccines.

Side Effects

Ruxience side effects include but are not limited to infusion-related reactions, fever, decreased lymphocytes, chills, infection, weakness, upper respiratory tract infections, nasopharyngitis, urinary tract infections, bronchitis, nausea, diarrhea, headache, muscle spasms, anemia, and swelling. Tell your healthcare provider right away if you experience worrisome or persistent side effects.

Talk to your healthcare provider about Ruxience.

Reference

Ruxience. New York, NY: Pfizer Labs; 2023.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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