Signifor Lar (Pasireotide)

Prescription medicineOnly Available By Prescription

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Description

Signifor LAR (Pasireotide) is a type of medication known as a somatostatin analog, which works by mimicking the hormone somatostatin. It attaches itself to somatostatin receptors, and by doing so, can help to control the overproduction of certain hormones. Medically, doctors prescribe Signifor LAR mainly to manage Cushing’s disease, a condition in which the pituitary gland releases too much cortisol. It is also approved for acromegaly. This long-acting formulation, designed for intramuscular injection, gradually releases Pasireotide over a period of time, aiming to maintain a steady hormonal balance.

Directions

Signifor LAR is an injectable medication that healthcare professionals administer intramuscularly, meaning it’s injected into a muscle. Patients typically receive a dose once every four weeks to manage conditions such as Cushing's disease and acromegaly. Initial dosing may vary based on the specific condition; however, for treating Cushing's disease, the starting dose is typically 10 mg, and for treating acromegaly, it is often 40 mg.

It's crucial to adhere to the dosage and administration schedule as detailed by a healthcare provider, since adjustments might be necessary based on the patient's response to therapy and any potential side effects. Patients should also be mindful of the medication’s visual appearance, avoiding use if the suspension appears discolored or contains particles.

Ingredients

The active ingredient in Signior LAR is Pasireotide.

Contraindications

There are no reported contraindications listed on the drug label.

Cautions

  • Before starting treatment with Signifor Lar, ensure you provide your healthcare provider with the following details:
    • Any medical conditions you have
    • Known allergies
    • A list of all medications you are currently taking
    • Information on whether you are pregnant or breastfeeding
  • Signifor LAR can cause high blood sugar, sometimes leading to diabetes or even ketoacidosis, a serious condition that can occur if high blood sugar is not treated. It’s important to monitor your blood sugar levels regularly, especially after starting or stopping treatment, or when your dose changes. If you experience signs of high blood sugar or ketoacidosis such as excessive thirst, frequent urination, or severe fatigue, contact your doctor immediately.
  • The medication can slow your heart rate or cause other changes in heart rhythm, known as QT prolongation, which can be serious. Before starting treatment and periodically during therapy, you’ll need an ECG test to monitor your heart's electrical activity and you may also need blood tests to check your body's electrolyte levels.
  • Signifor LAR can affect liver function, so your doctor will perform liver enzyme tests before you start treatment and during therapy to ensure your liver is working properly.
  • Treatment with Signifor LAR can lead to the formation of gallstones. If you experience symptoms like sudden and intense stomach pain, fever, or yellowing of the skin, it might be a complication from gallstones and you should contact your doctor right away.
  • Since Signifor LAR can impact the levels of certain hormones produced by the pituitary gland, your doctor will check these levels periodically and provide treatment if there are significant changes.

Side Effects

Common side effects of the Signifor LAR injection include diarrhea, headache, stomach pain, hair loss, nasal congestion, sore throat, nausea, and fatigue. Other issues include stomach bloating, low blood sugar, high blood pressure, limb swelling, and back pain. While typically manageable, these side effects can affect daily life.

More serious concerns include high blood sugar and diabetes, with potentially severe complications like ketoacidosis, which requires urgent medical attention. Symptoms include excessive thirst, frequent urination, nausea, and confusion. Signifor LAR can also slow heart rate, particularly in those with heart conditions or those on certain medications, with symptoms such as weakness and fainting.

The medication may cause liver function abnormalities and gallstones, leading to significant abdominal pain and potential gallbladder issues. Monitoring through blood tests and ultrasound is recommended to manage these risks. Additionally, the drug can decrease pituitary hormone levels, presenting as fatigue, dizziness, and weight loss, necessitating regular hormonal level assessments.

References:

  1. Signifor Lar (Pasireotide) Product Monograph. Lebanon, NJ: Recordati Rare Diseases Inc.; 2020.
  2. Signifor Lar (Pasireotide) Drug Label Information. Lebanon, NJ: Recordati Rare Diseases Inc.; 2020.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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