Also Known as Spiolto Respimat, Inspiolto Respimat
Only Available By Prescription
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| Strength | Pack Size | Qty | |
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Strength
2.5mcg/2.5mcg (60 puffs/30 doses/inhaler)
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Strength
2.5mcg/2.5mcg (60 puffs/30 doses/inhaler)
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Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray) is used in adults for long-term maintenance of chronic obstructive pulmonary disease (COPD).
Stiolto Respimat contains two medications that help open up the airways to allow for easier breathing: tiotropium bromide, an anticholinergic, and olodaterol, a long-acting beta2-adrenergic agonist.
Stiolto Respimat is not used for treating acute deterioration of COPD.
Stiolto Respimat is not used to treat asthma.
| Fact Table | |
| Formula |
C21H26N2O5 |
| License |
US FDA |
| Bioavailability |
~30% |
| Legal status |
Rx-Only |
| Chemical Name |
Tiotropium Bromide / Olodaterol |
| Elimination half-life |
7.5 hours |
| Dosage (Strength) |
2.5mcg/2.5mcg (60 puffs/30 doses/inhaler) |
| Pregnancy |
Consult Doctor |
| Brands |
Stiolto Respimat |
| Protein binding |
~60% |
| PubChem CID |
11504295 |
| MedlinePlus |
a615019 |
| ChEBI |
82700 |
| ATC code |
R03AC19 |
| DrugBank |
DB09080 |
| KEGG |
D10145 |
| Routes of administration |
Inhalation |
Follow the instructions that come with your Stiolto Respimat prescription. Don't hesitate to talk to your doctor or pharmacist about any questions or concerns you have about your prescription.
Stiolto Respimat comes in an inhalation spray for inhalation use. 2.5 mcg of tiotropium and 2.5 mcg of olodaterol is provided in each puff.
Recommended dosage:
Inhale two puffs by mouth one time a day at the same time each day.
Tiotropium bromide, an anticholinergic, and olodaterol, a beta2-adrenergic agonist, are the active ingredients in Stiolto Respimat.
Water for injection, benzalkonium chloride, edetate disodium, and hydrochloric acid are the inactive ingredients contained in Stiolto Respimat.
Using Stiolto Respimat without an inhaled corticosteroid is not recommended in patients with asthma.
Avoid using Stiolto Respimat if you are allergic to tiotropium, ipratropium, olodaterol, or any of the other ingredients in Stiolto Respimat.
Stiolto Respimat can cause nasopharyngitis, cough, and back pain. The medication can also cause other side effects, so call your doctor right away if you have side effects that get worse or won't go away.
Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray), for oral inhalation use. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2021.
What is Stiolto Respimat used for?
Stiolto Respimat helps adults with COPD breathe better and control symptoms. It's a spray with two medications: tiotropium and olodaterol. Take 2 puffs daily.
How to use Stiolto Respimat?
Follow the instructions to prepare the inhaler. Press the button to release the mist and breathe it in. Take 2 puffs once a day at the same time.
How long does it take for Stiolto Respimat to work?
It starts working in 5 minutes after inhaling and lasts for 24 hours.
Is Stiolto Respimat a steroid?
No, it's steroid-free. It contains tiotropium and olodaterol instead.
Does Stiolto Respimat cause weight gain?
Studies did not find that it causes weight gain.
What are the disadvantages of Respimat?
Common side effects include cough, sore throat, and chest tightness. Serious side effects like chest pain need immediate medical attention.
Who should not use Stiolto?
Stiolto Respimat is not for treating asthma. It is intended only for COPD. Always keep a rescue inhaler handy for sudden symptoms.
What drugs interact with Stiolto?
Stiolto Respimat has major interactions with albuterol and certain antidepressants. It has moderate interactions with aspirin and lisinopril that require caution, and minor interactions with gabapentin and hydroxyzine should be noted.
Can you use Stiolto twice a day?
No, once daily (2 puffs) is sufficient to provide a 24-hour benefit.
How long does Stiolto Respimat last?
It works for 24 hours after one daily dose.
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