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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Symdeko (tezacaftor/ivacaftor) is an oral medication used to treat patients who are 6+ years old with cystic fibrosis.
Symdeko may be dispensed in the following tablet strengths:
| Fact Table | |
| Formula | C26H27F3N2O6 (Tezacaftor), C24H28N2O3 (Ivacaftor) |
| License | US FDA |
| Bioavailability | N/A (Bioavailability increases with fat-containing meals) |
| Legal status | Prescription only (Rx) |
| Chemical Name | Tezacaftor/Ivacaftor |
| Elimination half-life | 13 hours (Tezacaftor), 12 hours (Ivacaftor) |
| Dosage (Strength) | Tezacaftor 100 mg/Ivacaftor 150 mg (per tablet) |
| Pregnancy | Consult a doctor |
| Brands | Symdeko |
| Protein binding | 99% (Tezacaftor), 99% (Ivacaftor) |
| PubChem CID | 54767952 (Tezacaftor), 16220172 (Ivacaftor) |
| MedlinePlus | a618048 |
| ChEBI | 134722 (Tezacaftor), 90905 (Ivacaftor) |
| ATC code | R07AX31 |
| DrugBank | DB13941 (Tezacaftor), DB08820 (Ivacaftor) |
| KEGG | D10799 (Tezacaftor), D09910 (Ivacaftor) |
| Routes of administration | Oral |
Symdeko should be taken as directed by the prescribing doctor. The dosage depends on age, weight, and liver function.
Symdeko tablets should be kept between 20oC and 25oC (68oF and 77oF).
Consult the medication guide that comes with the Symdeko prescription for further usage instructions.
Any questions or concerns may be referred to the doctor or pharmacist.
Tezacaftor and ivacaftor are the active ingredients in Symdeko.
Croscarmellose sodium, hypromellose, hypromellose acetate succinate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, HPMC/hypromellose 2910, hydroxypropyl cellulose, talc, and titanium dioxide are the inactive ingredients in tezacaftor 50 mg/ivacaftor 75 mg fixed-dose combination tablets and ivacaftor 75 mg tablets.
Colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, carnauba wax, FD&C Blue #2, PEG 3350, polyvinyl alcohol, talc, titanium dioxide, ammonium hydroxide, iron oxide black, propylene glycol, and shellac are the inactive ingredients in the ivacaftor 75 mg tablet.
Croscarmellose sodium, hypromellose, hypromellose acetate succinate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, HPMC/hypromellose 2910, hydroxypropyl cellulose, iron oxide yellow, talc, and titanium dioxide are the inactive ingredients in tezacaftor 100 mg/ivacaftor 150 mg fixed-dose combination tablets and ivacaftor 150 mg tablets.
Colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, carnauba wax, FD&C Blue #2, PEG 3350, polyvinyl alcohol, talc, titanium dioxide, ammonium hydroxide, iron oxide black, propylene glycol, and shellac are the inactive ingredients in the ivacaftor 150 mg tablets.
There are no listed contraindications per the most recent Prescribing Information.
Side effects of Symdeko include but are not limited to headache, nausea, sinus congestion, and dizziness.
Call the doctor right away if you or your child has side effects that become bothersome or persistent.
Looking for a competitive cost of Symdeko? Here, you can buy Symdeko with a valid prescription.
Symdeko. Boston, MA: Vertex Pharmaceuticals Incorporated; 2023.
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