Tasigna (Nilotinib Hydrochloride)

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75mg
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150mg
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200mg
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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Tasigna, also known as Nilotinib Hydrochloride, is a targeted cancer therapy. It belongs to a class of drugs called tyrosine kinase inhibitors. These drugs work by blocking specific proteins involved in the growth and spread of cancer cells. Tasigna comes in capsules, available in 50 mg, 150 mg, and 200 mg strengths. This medication treats adults and some children with chronic myeloid leukemia (CML). It is particularly used in those who are newly diagnosed or resistant to prior therapies.

Directions

Tasigna is a medication that comes in capsule form and is taken by mouth. It should be taken twice a day, about 12 hours apart. It's important to take the capsules on an empty stomach, which means you shouldn't eat for at least two hours before and one hour after taking them. For adults who have just been diagnosed with a specific type of blood cancer called Ph+ Chronic Myeloid Leukemia, the typical dose is 300 mg taken twice daily. If someone has already tried other treatments without success, their doctor may change the Tasigna dosing based on how they respond or any side effects they experience.

Ingredients

The active ingredient in Tasigna is Nilotinib Hydrochloride.

Contraindications

Individuals should avoid taking or using this medication if any of the following apply:

  • Known long QTc prolongation or persistent QTc > 480 msec
  • Uncorrectable hypokalemia (low potassium levels) or hypomagnesemia (low magnesium levels)
  • Known hypersensitivity to Nilotinib

Cautions

  • Before starting treatment with Tasigna, tell your healthcare provider if you have:
    • Any existing health conditions
    • Any allergies
    • A list of all medications you are currently taking
    • Whether you are pregnant or breastfeeding
  • Regular blood tests will monitor blood cell counts during treatment. Treatment may need to be paused or adjusted if levels drop.
  • Tasigna may cause heart problems or blockages in arteries. Cardiovascular health will be evaluated before and during treatment, and risk factors will be managed.
  • Blood tests will check for elevated lipase levels. If abdominal pain occurs, treatment may be paused, and further tests may be required to check for pancreatitis.
  • Liver function will be monitored monthly or as needed. Symptoms like yellowing of the skin or dark urine should be reported immediately.
  • Tasigna may affect blood electrolyte levels, including potassium, calcium, or sodium. Electrolyte levels will be corrected before starting treatment and monitored during therapy.
  • Tasigna can increase the risk of bleeding. Notify a healthcare provider if unusual bleeding or bruising occurs.
  • Watch for unexpected weight gain, swelling, or shortness of breath. These symptoms will be monitored and managed as needed.
  • In children, Tasigna may affect growth and development. Growth will be monitored regularly during treatment.
  • Tasigna can harm a developing fetus. Women who could become pregnant should use effective contraception and discuss risks with a healthcare provider.
  • Some patients may qualify to stop Tasigna. Eligibility will be determined through specific tests, and frequent monitoring will ensure remission continues.

Side Effects

Tasigna can cause side effects like rash, itching, headache, nausea, fatigue, and muscle pain. Other common issues include constipation, diarrhea, stomach pain, and hair loss. Blood-related side effects such as low platelet count, low white blood cell count, and anemia may also occur and require regular blood tests. Most side effects are mild to moderate and can usually be managed without stopping the medication.

Serious side effects can include bone marrow suppression and heart rhythm changes. There may also be cardiovascular problems like blocked arteries and high blood pressure. It's important to watch for signs of pancreatitis, liver issues (like yellowing of the skin), and electrolyte imbalances. Tasigna may increase the risk of serious skin reactions or bleeding. Symptoms such as severe chest pain, fainting, irregular heartbeat, or swelling should be reported to a doctor right away.

References

  1. Tasigna (Nilotinib) Product Monograph. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2024.
  2. Tasigna (Nilotinib) Drug Label Information. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2024.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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